Compensatory T-Cell Regulation in Unaffected Relatives of SLE Patients, and Opposite IL-2/CD25-Mediated Effects Suggested by Coreferentiality Modeling

Constantin Fesel; Marta Barreto; Ricardo C. Ferreira; Nuno Costa; Lara L. Venda; Clara Pereira; Claudia Carvalho; Maria Francisca Morães-Fontes; Carlos M. Ferreira; Carlos Vasconcelos; João F. Viana; Eugenia Santos; Berta Martins; Jocelyne Demengeot; Astrid M. Vicente

doi:10.1371/journal.pone.0033992

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Open Access

Peer-reviewed

Research Article

Compensatory T-Cell Regulation in Unaffected Relatives of SLE Patients, and Opposite IL-2/CD25-Mediated Effects Suggested by Coreferentiality Modeling

Constantin Fesel ,

* E-mail: cfesel@igc.gulbenkian.pt

Affiliation Instituto Gulbenkian de Ciência, Oeiras, Portugal
⨯
Marta Barreto,

Affiliations Instituto Gulbenkian de Ciência, Oeiras, Portugal, Instituto Nacional de Saúde Dr Ricardo Jorge, IP, Lisboa, Portugal
⨯
Ricardo C. Ferreira,

Affiliations Instituto Gulbenkian de Ciência, Oeiras, Portugal, Juvenile Diabetes Research Foundation/Wellcome Trust Diabetes and Inflammation Laboratory, Department of Medical Genetics, Cambridge Institute for Medical Research, University of Cambridge, Cambridge, United Kingdom
⨯
Nuno Costa,

Affiliation Instituto Gulbenkian de Ciência, Oeiras, Portugal
⨯
Lara L. Venda,

Affiliations Instituto Gulbenkian de Ciência, Oeiras, Portugal, Department of Physiology, Anatomy and Genetics, University of Oxford, Oxford, United Kingdom
⨯
Clara Pereira,

Affiliations Instituto Gulbenkian de Ciência, Oeiras, Portugal, Instituto de Ciências Biomédicas Abel Salazar, Porto, Portugal
⨯
Claudia Carvalho,

Affiliation Instituto de Ciências Biomédicas Abel Salazar, Porto, Portugal
⨯
Maria Francisca Morães-Fontes,

Affiliations Instituto Gulbenkian de Ciência, Oeiras, Portugal, Clínica Universitária de Medicina II, Hospital de Santa Maria, Lisboa, Portugal
⨯
Carlos M. Ferreira,

Affiliations Associação dos Doentes com Lupus, Lisboa, Portugal, Clínica Universitária de Medicina II, Hospital de Santa Maria, Lisboa, Portugal
⨯
Carlos Vasconcelos,

Affiliations Instituto de Ciências Biomédicas Abel Salazar, Porto, Portugal, Unidade de Imunologia Clínica, Hospital de Santo António, EPE, Porto, Portugal
⨯
João F. Viana,

Affiliation Centro Hospitalar Lisboa Ocidental, EPE, Lisboa, Portugal
⨯
Eugenia Santos,

Affiliations Associação dos Doentes com Lupus, Lisboa, Portugal, Clínica Universitária de Medicina II, Hospital de Santa Maria, Lisboa, Portugal
⨯
Berta Martins,

Affiliation Instituto de Ciências Biomédicas Abel Salazar, Porto, Portugal
⨯
Jocelyne Demengeot,

Affiliation Instituto Gulbenkian de Ciência, Oeiras, Portugal
⨯
Astrid M. Vicente

Affiliations Instituto Gulbenkian de Ciência, Oeiras, Portugal, Instituto Nacional de Saúde Dr Ricardo Jorge, IP, Lisboa, Portugal
⨯

Compensatory T-Cell Regulation in Unaffected Relatives of SLE Patients, and Opposite IL-2/CD25-Mediated Effects Suggested by Coreferentiality Modeling

Constantin Fesel,
Marta Barreto,
Ricardo C. Ferreira,
Nuno Costa,
Lara L. Venda,
Clara Pereira,
Claudia Carvalho,
Maria Francisca Morães-Fontes,
Carlos M. Ferreira,
Carlos Vasconcelos

Published: March 29, 2012
https://doi.org/10.1371/journal.pone.0033992

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