Low-Dose Cd Induces Hepatic Gene Hypermethylation, along with the Persistent Reduction of Cell Death and Increase of Cell Proliferation in Rats and Mice

Bo Wang; Yang Li; Yi Tan; Xiao Miao; Xu-Dong Liu; Chen Shao; Xiao-Hui Yang; Subat Turdi; Li-Jie Ma; Jun Ren; Lu Cai

doi:10.1371/journal.pone.0033853

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Peer-reviewed

Research Article

Low-Dose Cd Induces Hepatic Gene Hypermethylation, along with the Persistent Reduction of Cell Death and Increase of Cell Proliferation in Rats and Mice

Bo Wang,

Affiliations Department of Pathophysiology, Prostate Diseases Prevention and Treatment Research Center, Norman Bethune College of Medicine, Jilin University, Changchun, Jilin, China, Department of Pathology, Inner Mongolia Forestry General Hospital, Yakeshi, Inner Mongolia, China, Department of Pediatrics, The University of Louisville, Louisville, Kentucky, United States of America
⨯
Yang Li,

Affiliation Department of Pathophysiology, Prostate Diseases Prevention and Treatment Research Center, Norman Bethune College of Medicine, Jilin University, Changchun, Jilin, China
⨯
Yi Tan,

Affiliation Department of Pediatrics, The University of Louisville, Louisville, Kentucky, United States of America
⨯
Xiao Miao,

Affiliations Department of Pediatrics, The University of Louisville, Louisville, Kentucky, United States of America, Department of Ophthalmology, The Second Hospital of Jilin University, Changchun, Jilin, China
⨯
Xu-Dong Liu,

Affiliation Department of Emergency, Affiliated Hospital, Inner Mongolia Medical College, Hohhot, Inner Mongolia, China
⨯
Chen Shao,

Affiliation Department of Pathophysiology, Prostate Diseases Prevention and Treatment Research Center, Norman Bethune College of Medicine, Jilin University, Changchun, Jilin, China
⨯
Xiao-Hui Yang,

Affiliation Center for Cardiovascular Research and Alternative Medicine, University of Wyoming, Laramie, Wyoming, United States of America
⨯
Subat Turdi,

Affiliation Center for Cardiovascular Research and Alternative Medicine, University of Wyoming, Laramie, Wyoming, United States of America
⨯
Li-Jie Ma ,

* E-mail: nmmalj@hotmail.com (LJM); l0cai001@louisville.edu (LC)

Affiliation Department of Pharmacology, Inner Mongolia Medical College, Hohhot, Inner Mongolia, China
⨯
Jun Ren,

Affiliation Center for Cardiovascular Research and Alternative Medicine, University of Wyoming, Laramie, Wyoming, United States of America
⨯
Lu Cai

* E-mail: nmmalj@hotmail.com (LJM); l0cai001@louisville.edu (LC)

Affiliations Department of Pediatrics, The University of Louisville, Louisville, Kentucky, United States of America, Departments of Radiation Oncology, Pharmacology and Toxicology, the University of Louisville, Louisville, Kentucky, United States of America
⨯

Low-Dose Cd Induces Hepatic Gene Hypermethylation, along with the Persistent Reduction of Cell Death and Increase of Cell Proliferation in Rats and Mice

Bo Wang,
Yang Li,
Yi Tan,
Xiao Miao,
Xu-Dong Liu,
Chen Shao,
Xiao-Hui Yang,
Subat Turdi,
Li-Jie Ma,
Jun Ren

Published: March 23, 2012
https://doi.org/10.1371/journal.pone.0033853

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DNA methylation
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Apoptosis
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