Analysis Method and Experimental Conditions Affect Computed Circadian Phase from Melatonin Data

Hadassa Klerman; Melissa A. St. Hilaire; Richard E. Kronauer; Joshua J. Gooley; Claude Gronfier; Joseph T. Hull; Steven W. Lockley; Nayantara Santhi; Wei Wang; Elizabeth B. Klerman

doi:10.1371/journal.pone.0033836

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Research Article

Analysis Method and Experimental Conditions Affect Computed Circadian Phase from Melatonin Data

Hadassa Klerman,

Affiliation Division of Sleep Medicine, Brigham and Women's Hospital, Boston, Massachusetts, United States of America
⨯
Melissa A. St. Hilaire,

Affiliations Division of Sleep Medicine, Brigham and Women's Hospital, Boston, Massachusetts, United States of America, Division of Sleep Medicine, Harvard Medical School, Boston, Massachusetts, United States of America
⨯
Richard E. Kronauer,

Affiliations Division of Sleep Medicine, Harvard Medical School, Boston, Massachusetts, United States of America, Graduate School of Arts and Sciences, Harvard University, Cambridge, Massachusetts, United States of America
⨯
Joshua J. Gooley,

Affiliations Division of Sleep Medicine, Brigham and Women's Hospital, Boston, Massachusetts, United States of America, Division of Sleep Medicine, Harvard Medical School, Boston, Massachusetts, United States of America, Duke University School of Medicine, National University of Singapore, Singapore, Singapore
⨯
Claude Gronfier,

Affiliations Division of Sleep Medicine, Brigham and Women's Hospital, Boston, Massachusetts, United States of America, Division of Sleep Medicine, Harvard Medical School, Boston, Massachusetts, United States of America, Inserm, U846, Stem Cell and Brain Research Institute, Lyon, France
⨯
Joseph T. Hull,

Affiliations Division of Sleep Medicine, Brigham and Women's Hospital, Boston, Massachusetts, United States of America, Division of Sleep Medicine, Harvard Medical School, Boston, Massachusetts, United States of America
⨯
Steven W. Lockley,

Affiliations Division of Sleep Medicine, Brigham and Women's Hospital, Boston, Massachusetts, United States of America, Division of Sleep Medicine, Harvard Medical School, Boston, Massachusetts, United States of America
⨯
Nayantara Santhi,

Affiliations Division of Sleep Medicine, Brigham and Women's Hospital, Boston, Massachusetts, United States of America, Division of Sleep Medicine, Harvard Medical School, Boston, Massachusetts, United States of America
⨯
Wei Wang,

Affiliations Division of Sleep Medicine, Brigham and Women's Hospital, Boston, Massachusetts, United States of America, Division of Sleep Medicine, Harvard Medical School, Boston, Massachusetts, United States of America
⨯
Elizabeth B. Klerman

* E-mail: ebklerman@hms.harvard.edu

Affiliations Division of Sleep Medicine, Brigham and Women's Hospital, Boston, Massachusetts, United States of America, Division of Sleep Medicine, Harvard Medical School, Boston, Massachusetts, United States of America
⨯

Analysis Method and Experimental Conditions Affect Computed Circadian Phase from Melatonin Data

Hadassa Klerman,
Melissa A. St. Hilaire,
Richard E. Kronauer,
Joshua J. Gooley,
Claude Gronfier,
Joseph T. Hull,
Steven W. Lockley,
Nayantara Santhi,
Wei Wang,
Elizabeth B. Klerman

Published: April 12, 2012
https://doi.org/10.1371/journal.pone.0033836

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Melatonin
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Chronobiology
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Curve fitting
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Secretion
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Circadian rhythms
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Phase determination
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