Exploiting Adaptive Laboratory Evolution of Streptomyces clavuligerus for Antibiotic Discovery and Overproduction

• Pep Charusanti,

  Affiliation Department of Bioengineering, University of California San Diego, La Jolla, California, United States of America

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• Nicole L. Fong,

  Affiliation Department of Bioengineering, University of California San Diego, La Jolla, California, United States of America

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• Harish Nagarajan,

  Affiliations Department of Bioengineering, University of California San Diego, La Jolla, California, United States of America, Bioinformatics and Systems Biology Graduate Program, University of California San Diego, La Jolla, California, United States of America

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• Alban R. Pereira,

  Affiliation Center for Marine Biotechnology and Biomedicine, Scripps Institution of Oceanography and Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California San Diego, La Jolla, California, United States of America

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• Howard J. Li,

  Affiliation Department of Bioengineering, University of California San Diego, La Jolla, California, United States of America

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• Elisa A. Abate,

  Affiliation Department of Bioengineering, University of California San Diego, La Jolla, California, United States of America

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• Yongxuan Su,

  Affiliation Department of Chemistry and Biochemistry, University of California San Diego, La Jolla, California, United States of America

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• William H. Gerwick,

  Affiliation Center for Marine Biotechnology and Biomedicine, Scripps Institution of Oceanography and Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California San Diego, La Jolla, California, United States of America

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• Bernhard O. Palsson

  * E-mail: palsson@ucsd.edu

  Affiliation Department of Bioengineering, University of California San Diego, La Jolla, California, United States of America

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