A Genome-Wide RNAi Screen Identifies Regulators of Cholesterol-Modified Hedgehog Secretion in Drosophila

Reid Aikin; Alexandra Cervantes; Gisela D'Angelo; Laurent Ruel; Sandra Lacas-Gervais; Sébastien Schaub; Pascal Thérond

doi:10.1371/journal.pone.0033665

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Research Article

A Genome-Wide RNAi Screen Identifies Regulators of Cholesterol-Modified Hedgehog Secretion in Drosophila

Reid Aikin ,

Contributed equally to this work with: Reid Aikin, Alexandra Cervantes, Gisela D'Angelo

Current address: McGill University Health Centre, Montreal, Quebec, Canada

Affiliations CNRS UMR 7277, Inserm UMR 1091, Institut de Biologie Valrose (iBV), Centre de Biochimie, Nice, France, Université de Nice-Sophia Antipolis, Nice, France
⨯
Alexandra Cervantes ,

Contributed equally to this work with: Reid Aikin, Alexandra Cervantes, Gisela D'Angelo

Affiliations CNRS UMR 7277, Inserm UMR 1091, Institut de Biologie Valrose (iBV), Centre de Biochimie, Nice, France, Université de Nice-Sophia Antipolis, Nice, France
⨯
Gisela D'Angelo ,

Contributed equally to this work with: Reid Aikin, Alexandra Cervantes, Gisela D'Angelo

Affiliations CNRS UMR 7277, Inserm UMR 1091, Institut de Biologie Valrose (iBV), Centre de Biochimie, Nice, France, Université de Nice-Sophia Antipolis, Nice, France
⨯
Laurent Ruel,

Affiliations CNRS UMR 7277, Inserm UMR 1091, Institut de Biologie Valrose (iBV), Centre de Biochimie, Nice, France, Université de Nice-Sophia Antipolis, Nice, France
⨯
Sandra Lacas-Gervais,

Affiliation Centre Commun de Microscopie Appliquée (CCMA), Université de Nice-Sophia Antipolis, Nice, France
⨯
Sébastien Schaub,

Affiliations CNRS UMR 7277, Inserm UMR 1091, Institut de Biologie Valrose (iBV), Centre de Biochimie, Nice, France, Université de Nice-Sophia Antipolis, Nice, France
⨯
Pascal Thérond

* E-mail: therond@unice.fr

Affiliations CNRS UMR 7277, Inserm UMR 1091, Institut de Biologie Valrose (iBV), Centre de Biochimie, Nice, France, Université de Nice-Sophia Antipolis, Nice, France
⨯

A Genome-Wide RNAi Screen Identifies Regulators of Cholesterol-Modified Hedgehog Secretion in Drosophila

Reid Aikin,
Alexandra Cervantes,
Gisela D'Angelo,
Laurent Ruel,
Sandra Lacas-Gervais,
Sébastien Schaub,
Pascal Thérond

Published: March 14, 2012
https://doi.org/10.1371/journal.pone.0033665

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Secretion
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Cholesterol
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Golgi apparatus
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Protein secretion
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Lipids
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Transfection
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RNA interference
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Regulator genes
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