Targeting the Lactate Transporter MCT1 in Endothelial Cells Inhibits Lactate-Induced HIF-1 Activation and Tumor Angiogenesis

• Pierre Sonveaux ,

  * E-mail: pierre.sonveaux@uclouvain.be

  Affiliations Pole of Pharmacology, Institute of Experimental and Clinical Research (IREC), Université catholique de Louvain (UCL), Brussels, Belgium, Department of Radiation Oncology, Duke University Medical Center, Durham, North Carolina, United States of America

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• Tamara Copetti,

  Affiliation Pole of Pharmacology, Institute of Experimental and Clinical Research (IREC), Université catholique de Louvain (UCL), Brussels, Belgium

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• Christophe J. De Saedeleer,

  Affiliation Pole of Pharmacology, Institute of Experimental and Clinical Research (IREC), Université catholique de Louvain (UCL), Brussels, Belgium

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• Frédérique Végran,

  Affiliation Pole of Pharmacology, Institute of Experimental and Clinical Research (IREC), Université catholique de Louvain (UCL), Brussels, Belgium

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• Julien Verrax,

  Affiliation Pole of Pharmacology, Institute of Experimental and Clinical Research (IREC), Université catholique de Louvain (UCL), Brussels, Belgium

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• Kelly M. Kennedy,

  Affiliation Department of Radiation Oncology, Duke University Medical Center, Durham, North Carolina, United States of America

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• Eui Jung Moon,

  Affiliation Department of Pathology, Duke University Medical Center, Durham, North Carolina, United States of America

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• Suveera Dhup,

  Affiliation Pole of Pharmacology, Institute of Experimental and Clinical Research (IREC), Université catholique de Louvain (UCL), Brussels, Belgium

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• Pierre Danhier,

  Affiliation Nuclear Magnetic Resonance Research Group, Louvain Drug Research Institute (LDRI), Université catholique de Louvain (UCL), Brussels, Belgium

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• Françoise Frérart,

  Affiliation Pole of Pharmacology, Institute of Experimental and Clinical Research (IREC), Université catholique de Louvain (UCL), Brussels, Belgium

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• Bernard Gallez,

  Affiliation Nuclear Magnetic Resonance Research Group, Louvain Drug Research Institute (LDRI), Université catholique de Louvain (UCL), Brussels, Belgium

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• Anthony Ribeiro,

  Affiliation Department of Radiology and Biochemistry, Duke University Medical Center, Durham, North Carolina, United States of America

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• Carine Michiels,

  Affiliation Laboratory of Biochemistry and Cellular Biology, University of Namur (FUNDP), Namur, Belgium

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• Mark W. Dewhirst ,

  Contributed equally to this work with: Mark W. Dewhirst, Olivier Feron

  Affiliations Department of Radiation Oncology, Duke University Medical Center, Durham, North Carolina, United States of America, Department of Pathology, Duke University Medical Center, Durham, North Carolina, United States of America

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• Olivier Feron

  Contributed equally to this work with: Mark W. Dewhirst, Olivier Feron

  Affiliation Pole of Pharmacology, Institute of Experimental and Clinical Research (IREC), Université catholique de Louvain (UCL), Brussels, Belgium

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