Invariant NKT Cells Drive Hepatic Cytokinic Microenvironment Favoring Efficient Granuloma Formation and Early Control of Leishmania donovani Infection

Florence Robert-Gangneux; Anne-Sophie Drogoul; Octavie Rostan; Claire Piquet-Pellorce; Jérome Cayon; Mariette Lisbonne; André Herbelin; Hugues Gascan; Claude Guiguen; Michel Samson; Jean-Pierre Gangneux

doi:10.1371/journal.pone.0033413

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Peer-reviewed

Research Article

Invariant NKT Cells Drive Hepatic Cytokinic Microenvironment Favoring Efficient Granuloma Formation and Early Control of Leishmania donovani Infection

Florence Robert-Gangneux ,

* E-mail: florence.robert-gangneux@univ-rennes1.fr

Affiliations Centre Hospitalier Universitaire de Rennes, Laboratoire de Parasitologie, Rennes, France, INSERM U1085, IRSET (Institut de Recherche en Santé Environnement Travail), Université Rennes 1, Rennes, France
⨯
Anne-Sophie Drogoul,

Affiliations Centre Hospitalier Universitaire de Rennes, Laboratoire de Parasitologie, Rennes, France, INSERM U1085, IRSET (Institut de Recherche en Santé Environnement Travail), Université Rennes 1, Rennes, France
⨯
Octavie Rostan,

Affiliation INSERM U1085, IRSET (Institut de Recherche en Santé Environnement Travail), Université Rennes 1, Rennes, France
⨯
Claire Piquet-Pellorce,

Affiliation INSERM U1085, IRSET (Institut de Recherche en Santé Environnement Travail), Université Rennes 1, Rennes, France
⨯
Jérome Cayon,

Affiliation INSERM U564, Université d’Angers, Angers, France
⨯
Mariette Lisbonne,

Affiliation INSERM U1085, IRSET (Institut de Recherche en Santé Environnement Travail), Université Rennes 1, Rennes, France
⨯
André Herbelin,

Affiliation INSERM U935, Université Paris-Sud 11, Villejuif, France
⨯
Hugues Gascan,

Affiliation INSERM U564, Université d’Angers, Angers, France
⨯
Claude Guiguen,

Affiliation Centre Hospitalier Universitaire de Rennes, Laboratoire de Parasitologie, Rennes, France
⨯
Michel Samson,

Affiliation INSERM U1085, IRSET (Institut de Recherche en Santé Environnement Travail), Université Rennes 1, Rennes, France
⨯
Jean-Pierre Gangneux

Affiliations Centre Hospitalier Universitaire de Rennes, Laboratoire de Parasitologie, Rennes, France, INSERM U1085, IRSET (Institut de Recherche en Santé Environnement Travail), Université Rennes 1, Rennes, France
⨯

Invariant NKT Cells Drive Hepatic Cytokinic Microenvironment Favoring Efficient Granuloma Formation and Early Control of Leishmania donovani Infection

Florence Robert-Gangneux,
Anne-Sophie Drogoul,
Octavie Rostan,
Claire Piquet-Pellorce,
Jérome Cayon,
Mariette Lisbonne,
André Herbelin,
Hugues Gascan,
Claude Guiguen,
Michel Samson

Published: March 22, 2012
https://doi.org/10.1371/journal.pone.0033413

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Granulomas
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Parasitic diseases
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Chemokines
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Leishmania donovani
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T cells
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