Cellular Immunity Confers Transient Protection in Experimental Buruli Ulcer following BCG or Mycolactone-Negative Mycobacterium ulcerans Vaccination

Alexandra G. Fraga; Teresa G. Martins; Egídio Torrado; Kris Huygen; Françoise Portaels; Manuel T. Silva; António G. Castro; Jorge Pedrosa

doi:10.1371/journal.pone.0033406

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Open Access

Peer-reviewed

Research Article

Cellular Immunity Confers Transient Protection in Experimental Buruli Ulcer following BCG or Mycolactone-Negative Mycobacterium ulcerans Vaccination

Alexandra G. Fraga,

Affiliations Life and Health Sciences Research Institute (ICVS), School of Health Sciences, University of Minho, Braga, Portugal, ICVS/3B's - PT Government Associate Laboratory, Braga/Guimarães, Portugal
⨯
Teresa G. Martins,

Affiliations Life and Health Sciences Research Institute (ICVS), School of Health Sciences, University of Minho, Braga, Portugal, ICVS/3B's - PT Government Associate Laboratory, Braga/Guimarães, Portugal
⨯
Egídio Torrado,

Current address: Trudeau Institute, Saranac Lake, New York, United States of America

Affiliation Life and Health Sciences Research Institute (ICVS), School of Health Sciences, University of Minho, Braga, Portugal
⨯
Kris Huygen,

Affiliation Scientific Service Immunology, Scientific Institute of Public Health WIV-ISP (Site Ukkel), Brussels, Belgium
⨯
Françoise Portaels,

Affiliation Mycobacteriology Unit, Department of Microbiology, Institute of Tropical Medicine, Antwerp, Belgium
⨯
Manuel T. Silva,

Affiliation Institute for Molecular and Cell Biology, Porto, Portugal
⨯
António G. Castro,

Affiliations Life and Health Sciences Research Institute (ICVS), School of Health Sciences, University of Minho, Braga, Portugal, ICVS/3B's - PT Government Associate Laboratory, Braga/Guimarães, Portugal
⨯
Jorge Pedrosa

* E-mail: jpedrosa@ecsaude.uminho.pt

Affiliations Life and Health Sciences Research Institute (ICVS), School of Health Sciences, University of Minho, Braga, Portugal, ICVS/3B's - PT Government Associate Laboratory, Braga/Guimarães, Portugal
⨯

Cellular Immunity Confers Transient Protection in Experimental Buruli Ulcer following BCG or Mycolactone-Negative Mycobacterium ulcerans Vaccination

Alexandra G. Fraga,
Teresa G. Martins,
Egídio Torrado,
Kris Huygen,
Françoise Portaels,
Manuel T. Silva,
António G. Castro,
Jorge Pedrosa

Published: March 8, 2012
https://doi.org/10.1371/journal.pone.0033406

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Mycobacterium ulcerans
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Vaccination and immunization
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Immune response
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Buruli ulcer
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T cells
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