Activation of PI3K/AKT and MAPK Pathway through a PDGFRβ-Dependent Feedback Loop Is Involved in Rapamycin Resistance in Hepatocellular Carcinoma

Quan-Lin Li; Fang-Ming Gu; Zheng Wang; Jia-Hao Jiang; Li-Qing Yao; Chang-Jun Tan; Xiao-Yong Huang; Ai-Wu Ke; Zhi Dai; Jia Fan; Jian Zhou

doi:10.1371/journal.pone.0033379

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Peer-reviewed

Research Article

Activation of PI3K/AKT and MAPK Pathway through a PDGFRβ-Dependent Feedback Loop Is Involved in Rapamycin Resistance in Hepatocellular Carcinoma

Quan-Lin Li ,

Contributed equally to this work with: Quan-Lin Li, Fang-Ming Gu, Zheng Wang, Jia-Hao Jiang

Affiliations Department of Liver Surgery, Liver Cancer Institute, Zhongshan Hospital, Fudan University, Key Laboratory of Carcinogenesis and Cancer Invasion of Ministry of Education, Shanghai, People's Republic of China, Endoscopy Center and Endoscopy Research Institute, Zhongshan Hospital, Fudan University, Shanghai, People's Republic of China
⨯
Fang-Ming Gu ,

Contributed equally to this work with: Quan-Lin Li, Fang-Ming Gu, Zheng Wang, Jia-Hao Jiang

Affiliation Department of Liver Surgery, Liver Cancer Institute, Zhongshan Hospital, Fudan University, Key Laboratory of Carcinogenesis and Cancer Invasion of Ministry of Education, Shanghai, People's Republic of China
⨯
Zheng Wang ,

Contributed equally to this work with: Quan-Lin Li, Fang-Ming Gu, Zheng Wang, Jia-Hao Jiang

Affiliation Department of Liver Surgery, Liver Cancer Institute, Zhongshan Hospital, Fudan University, Key Laboratory of Carcinogenesis and Cancer Invasion of Ministry of Education, Shanghai, People's Republic of China
⨯
Jia-Hao Jiang ,

Contributed equally to this work with: Quan-Lin Li, Fang-Ming Gu, Zheng Wang, Jia-Hao Jiang

Affiliation Department of Liver Surgery, Liver Cancer Institute, Zhongshan Hospital, Fudan University, Key Laboratory of Carcinogenesis and Cancer Invasion of Ministry of Education, Shanghai, People's Republic of China
⨯
Li-Qing Yao,

Affiliation Endoscopy Center and Endoscopy Research Institute, Zhongshan Hospital, Fudan University, Shanghai, People's Republic of China
⨯
Chang-Jun Tan,

Affiliation Department of Liver Surgery, Liver Cancer Institute, Zhongshan Hospital, Fudan University, Key Laboratory of Carcinogenesis and Cancer Invasion of Ministry of Education, Shanghai, People's Republic of China
⨯
Xiao-Yong Huang,

Affiliation Department of Liver Surgery, Liver Cancer Institute, Zhongshan Hospital, Fudan University, Key Laboratory of Carcinogenesis and Cancer Invasion of Ministry of Education, Shanghai, People's Republic of China
⨯
Ai-Wu Ke,

Affiliation Department of Liver Surgery, Liver Cancer Institute, Zhongshan Hospital, Fudan University, Key Laboratory of Carcinogenesis and Cancer Invasion of Ministry of Education, Shanghai, People's Republic of China
⨯
Zhi Dai,

Affiliations Department of Liver Surgery, Liver Cancer Institute, Zhongshan Hospital, Fudan University, Key Laboratory of Carcinogenesis and Cancer Invasion of Ministry of Education, Shanghai, People's Republic of China, Shanghai Key Laboratory of Organ Transplantation, Shanghai, People's Republic of China
⨯
Jia Fan ,

* E-mail: jiafan99@yahoo.com (JF); zhou.jian@zs-hospital.sh.cn (JZ)

Affiliations Department of Liver Surgery, Liver Cancer Institute, Zhongshan Hospital, Fudan University, Key Laboratory of Carcinogenesis and Cancer Invasion of Ministry of Education, Shanghai, People's Republic of China, Shanghai Key Laboratory of Organ Transplantation, Shanghai, People's Republic of China
⨯
Jian Zhou

* E-mail: jiafan99@yahoo.com (JF); zhou.jian@zs-hospital.sh.cn (JZ)

Affiliations Department of Liver Surgery, Liver Cancer Institute, Zhongshan Hospital, Fudan University, Key Laboratory of Carcinogenesis and Cancer Invasion of Ministry of Education, Shanghai, People's Republic of China, Shanghai Key Laboratory of Organ Transplantation, Shanghai, People's Republic of China
⨯

Activation of PI3K/AKT and MAPK Pathway through a PDGFRβ-Dependent Feedback Loop Is Involved in Rapamycin Resistance in Hepatocellular Carcinoma

Quan-Lin Li,
Fang-Ming Gu,
Zheng Wang,
Jia-Hao Jiang,
Li-Qing Yao,
Chang-Jun Tan,
Xiao-Yong Huang,
Ai-Wu Ke,
Zhi Dai,
Jia Fan

Published: March 9, 2012
https://doi.org/10.1371/journal.pone.0033379

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