Toolbox for Non-Intrusive Structural and Functional Analysis of Recombinant VLP Based Vaccines: A Case Study with Hepatitis B Vaccine

Anke M. Mulder; Bridget Carragher; Victoria Towne; Yuan Meng; Yang Wang; Lance Dieter; Clinton S. Potter; Michael W. Washabaugh; Robert D. Sitrin; Qinjian Zhao

doi:10.1371/journal.pone.0033235

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Open Access

Peer-reviewed

Research Article

Toolbox for Non-Intrusive Structural and Functional Analysis of Recombinant VLP Based Vaccines: A Case Study with Hepatitis B Vaccine

Anke M. Mulder ,

* E-mail: mulder@nanoimagingservices.com (AMM); qinjianzhao@gmail.com (QZ)

Affiliation Department of Research & Development, NanoImaging Services, La Jolla, California, United States of America
⨯
Bridget Carragher,

Affiliation Department of Research & Development, NanoImaging Services, La Jolla, California, United States of America
⨯
Victoria Towne,

Affiliation Merck Manufacturing Division, Vaccine Manufacturing Science and Commercialization, West Point, Pennsylvania, United States of America
⨯
Yuan Meng,

Affiliation Vaccine Analytical R&D, Merck Research Laboratories, West Point, Pennsylvania, United States of America
⨯
Yang Wang,

Current address: Sino Biologicals, Inc., Beijing, China

Affiliation Vaccine Analytical R&D, Merck Research Laboratories, West Point, Pennsylvania, United States of America
⨯
Lance Dieter,

Affiliation Vaccine Bioprocess R&D, Merck Research Laboratories, West Point, Pennsylvania, United States of America
⨯
Clinton S. Potter,

Affiliation Department of Research & Development, NanoImaging Services, La Jolla, California, United States of America
⨯
Michael W. Washabaugh,

Current address: MedImmune, Gaithersburg, Maryland, United States of America

Affiliation Vaccine Analytical R&D, Merck Research Laboratories, West Point, Pennsylvania, United States of America
⨯
Robert D. Sitrin,

Current address: SitrinSolutions, LLC, Lafayette Hill, Pennsylvania, United States of America

Affiliation Merck Manufacturing Division, Vaccine Manufacturing Science and Commercialization, West Point, Pennsylvania, United States of America
⨯
Qinjian Zhao

* E-mail: mulder@nanoimagingservices.com (AMM); qinjianzhao@gmail.com (QZ)

Current address: School of Public Health, Xiamen University, Xiamen, Fujian, China

Affiliation Vaccine Analytical R&D, Merck Research Laboratories, West Point, Pennsylvania, United States of America
⨯

Toolbox for Non-Intrusive Structural and Functional Analysis of Recombinant VLP Based Vaccines: A Case Study with Hepatitis B Vaccine

Anke M. Mulder,
Bridget Carragher,
Victoria Towne,
Yuan Meng,
Yang Wang,
Lance Dieter,
Clinton S. Potter,
Michael W. Washabaugh,
Robert D. Sitrin,
Qinjian Zhao

Published: April 6, 2012
https://doi.org/10.1371/journal.pone.0033235

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