Validation Study of Existing Gene Expression Signatures for Anti-TNF Treatment in Patients with Rheumatoid Arthritis

Erik J. M. Toonen; Christian Gilissen; Barbara Franke; Wietske Kievit; Agnes M. Eijsbouts; Alfons A. den Broeder; Simon V. van Reijmersdal; Joris A. Veltman; Hans Scheffer; Timothy R. D. J. Radstake; Piet L. C. M. van Riel; Pilar Barrera; Marieke J. H. Coenen

doi:10.1371/journal.pone.0033199

Loading metrics

Open Access

Peer-reviewed

Research Article

Validation Study of Existing Gene Expression Signatures for Anti-TNF Treatment in Patients with Rheumatoid Arthritis

Erik J. M. Toonen,

Affiliation Department of Medicine, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
⨯
Christian Gilissen,

Affiliation Department of Human Genetics, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
⨯
Barbara Franke,

Affiliation Department of Human Genetics, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
⨯
Wietske Kievit,

Affiliation Department of Rheumatology, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
⨯
Agnes M. Eijsbouts,

Affiliation Department of Rheumatology of the St Maartenskliniek, Nijmegen, The Netherlands
⨯
Alfons A. den Broeder,

Affiliation Department of Rheumatology of the St Maartenskliniek, Nijmegen, The Netherlands
⨯
Simon V. van Reijmersdal,

Affiliation Department of Human Genetics, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
⨯
Joris A. Veltman,

Affiliation Department of Human Genetics, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
⨯
Hans Scheffer,

Affiliation Department of Human Genetics, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
⨯
Timothy R. D. J. Radstake,

Affiliation Department of Rheumatology, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
⨯
Piet L. C. M. van Riel,

Affiliation Department of Rheumatology, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
⨯
Pilar Barrera,

Affiliation Department of Rheumatology, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
⨯
Marieke J. H. Coenen

* E-mail: m.coenen@gen.umcn.nl

Affiliation Department of Human Genetics, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
⨯

Validation Study of Existing Gene Expression Signatures for Anti-TNF Treatment in Patients with Rheumatoid Arthritis

Erik J. M. Toonen,
Christian Gilissen,
Barbara Franke,
Wietske Kievit,
Agnes M. Eijsbouts,
Alfons A. den Broeder,
Simon V. van Reijmersdal,
Joris A. Veltman,
Hans Scheffer,
Timothy R. D. J. Radstake

Published: March 21, 2012
https://doi.org/10.1371/journal.pone.0033199

Reader Comments (2)

Post a new comment on this article

1 Response

29 Dec 2016
20:56 GMT
Most Recent

Letter to the Editor: Prerequisites to Define and to Validate Therapy-Predicitive Blood Biomarkers Posted by bmrjnst on 02 Oct 2012 at 13:39 GMT

Subject Areas
?

For more information about PLOS Subject Areas, click here.
We want your feedback. Do these Subject Areas make sense for this article? Click the target next to the incorrect Subject Area and let us know. Thanks for your help!

Gene expression
Is the Subject Area "Gene expression" applicable to this article?

Thanks for your feedback.
Rheumatoid arthritis
Is the Subject Area "Rheumatoid arthritis" applicable to this article?

Thanks for your feedback.
Blood
Is the Subject Area "Blood" applicable to this article?

Thanks for your feedback.
Gene prediction
Is the Subject Area "Gene prediction" applicable to this article?

Thanks for your feedback.
Cancer treatment
Is the Subject Area "Cancer treatment" applicable to this article?

Thanks for your feedback.
Biopsy
Is the Subject Area "Biopsy" applicable to this article?

Thanks for your feedback.
Cytokines
Is the Subject Area "Cytokines" applicable to this article?

Thanks for your feedback.
Rheumatology
Is the Subject Area "Rheumatology" applicable to this article?

Thanks for your feedback.