Granzyme B Cleaves Decorin, Biglycan and Soluble Betaglycan, Releasing Active Transforming Growth Factor-β1

Wendy A. Boivin; Marlo Shackleford; Amanda Vanden Hoek; Hongyan Zhao; Tillie L. Hackett; Darryl A. Knight; David J. Granville

doi:10.1371/journal.pone.0033163

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Peer-reviewed

Research Article

Granzyme B Cleaves Decorin, Biglycan and Soluble Betaglycan, Releasing Active Transforming Growth Factor-β1

Wendy A. Boivin,

Affiliations UBC James Hogg Research Centre, Institute for Heart+Lung Health, St. Paul's Hospital, Vancouver, British Columbia, Canada, Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, British Columbia, Canada
⨯
Marlo Shackleford,

Affiliation UBC James Hogg Research Centre, Institute for Heart+Lung Health, St. Paul's Hospital, Vancouver, British Columbia, Canada
⨯
Amanda Vanden Hoek,

Affiliation Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, British Columbia, Canada
⨯
Hongyan Zhao,

Affiliations UBC James Hogg Research Centre, Institute for Heart+Lung Health, St. Paul's Hospital, Vancouver, British Columbia, Canada, Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, British Columbia, Canada
⨯
Tillie L. Hackett,

Affiliations UBC James Hogg Research Centre, Institute for Heart+Lung Health, St. Paul's Hospital, Vancouver, British Columbia, Canada, Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, British Columbia, Canada
⨯
Darryl A. Knight,

Affiliations UBC James Hogg Research Centre, Institute for Heart+Lung Health, St. Paul's Hospital, Vancouver, British Columbia, Canada, Department of Anesthesiology, Pharmacology and Therapeutics, University of British Columbia, Vancouver, British Columbia, Canada
⨯
David J. Granville

* E-mail: david.granville@hli.ubc.ca

Affiliations UBC James Hogg Research Centre, Institute for Heart+Lung Health, St. Paul's Hospital, Vancouver, British Columbia, Canada, Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, British Columbia, Canada
⨯

Granzyme B Cleaves Decorin, Biglycan and Soluble Betaglycan, Releasing Active Transforming Growth Factor-β1

Wendy A. Boivin,
Marlo Shackleford,
Amanda Vanden Hoek,
Hongyan Zhao,
Tillie L. Hackett,
Darryl A. Knight,
David J. Granville

Published: March 30, 2012
https://doi.org/10.1371/journal.pone.0033163

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