Simulated-Physiological Loading Conditions Preserve Biological and Mechanical Properties of Caprine Lumbar Intervertebral Discs in Ex Vivo Culture

Cornelis P. L. Paul; Hendrik A. Zuiderbaan; Behrouz Zandieh Doulabi; Albert J. van der Veen; Peter M. van de Ven; Theo H. Smit; Marco N. Helder; Barend J. van Royen; Margriet G. Mullender

doi:10.1371/journal.pone.0033147

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Peer-reviewed

Research Article

Simulated-Physiological Loading Conditions Preserve Biological and Mechanical Properties of Caprine Lumbar Intervertebral Discs in Ex Vivo Culture

Cornelis P. L. Paul,

Affiliations Department of Orthopedic Surgery, VU University Medical Center, Amsterdam, The Netherlands, Research institute MOVE, VU University Medical Center, Amsterdam, The Netherlands
⨯
Hendrik A. Zuiderbaan,

Affiliation Department of Orthopedic Surgery, VU University Medical Center, Amsterdam, The Netherlands
⨯
Behrouz Zandieh Doulabi,

Affiliations Department of Orthopedic Surgery, VU University Medical Center, Amsterdam, The Netherlands, Faculty of Oral Cell Biology, Academic Centre of Dentistry Amsterdam, Amsterdam, The Netherlands
⨯
Albert J. van der Veen,

Affiliations Department of Orthopedic Surgery, VU University Medical Center, Amsterdam, The Netherlands, Department of Physics and Medical Technology, VU University Medical Center, Amsterdam, The Netherlands
⨯
Peter M. van de Ven,

Affiliation Department of Epidemiology and Biostatistics, VU University Medical Center, Amsterdam, The Netherlands
⨯
Theo H. Smit,

Affiliations Department of Orthopedic Surgery, VU University Medical Center, Amsterdam, The Netherlands, Research institute MOVE, VU University Medical Center, Amsterdam, The Netherlands, Skeletal Tissue Engineering Group Amsterdam, VU University Medical Center, Amsterdam, The Netherlands
⨯
Marco N. Helder,

Affiliations Department of Orthopedic Surgery, VU University Medical Center, Amsterdam, The Netherlands, Research institute MOVE, VU University Medical Center, Amsterdam, The Netherlands, Skeletal Tissue Engineering Group Amsterdam, VU University Medical Center, Amsterdam, The Netherlands
⨯
Barend J. van Royen,

Affiliations Department of Orthopedic Surgery, VU University Medical Center, Amsterdam, The Netherlands, Research institute MOVE, VU University Medical Center, Amsterdam, The Netherlands, Skeletal Tissue Engineering Group Amsterdam, VU University Medical Center, Amsterdam, The Netherlands
⨯
Margriet G. Mullender

* E-mail: m.mullender@vumc.nl

Affiliations Department of Orthopedic Surgery, VU University Medical Center, Amsterdam, The Netherlands, Research institute MOVE, VU University Medical Center, Amsterdam, The Netherlands, Skeletal Tissue Engineering Group Amsterdam, VU University Medical Center, Amsterdam, The Netherlands, Department of Plastic, Reconstructive and Hand Surgery, VU University Medical Center, Amsterdam, The Netherlands
⨯

Simulated-Physiological Loading Conditions Preserve Biological and Mechanical Properties of Caprine Lumbar Intervertebral Discs in Ex Vivo Culture

Cornelis P. L. Paul,
Hendrik A. Zuiderbaan,
Behrouz Zandieh Doulabi,
Albert J. van der Veen,
Peter M. van de Ven,
Theo H. Smit,
Marco N. Helder,
Barend J. van Royen,
Margriet G. Mullender

Published: March 13, 2012
https://doi.org/10.1371/journal.pone.0033147

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