PTPN22.6, a Dominant Negative Isoform of PTPN22 and Potential Biomarker of Rheumatoid Arthritis

Hui-Hsin Chang; Tzong-Shyuan Tai; Bing Lu; Christine Iannaccone; Manuela Cernadas; Michael Weinblatt; Nancy Shadick; Shi-Chuen Miaw; I-Cheng Ho

doi:10.1371/journal.pone.0033067

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Research Article

PTPN22.6, a Dominant Negative Isoform of PTPN22 and Potential Biomarker of Rheumatoid Arthritis

Hui-Hsin Chang,

Affiliations Division of Rheumatology, Immunology, and Allergy, Department of Medicine, Brigham and Women's Hospital, Boston, Massachusetts, United States of America, Harvard Medical School, Boston, Massachusetts, United States of America
⨯
Tzong-Shyuan Tai,

Affiliations Division of Rheumatology, Immunology, and Allergy, Department of Medicine, Brigham and Women's Hospital, Boston, Massachusetts, United States of America, Harvard Medical School, Boston, Massachusetts, United States of America
⨯
Bing Lu,

Affiliations Division of Rheumatology, Immunology, and Allergy, Department of Medicine, Brigham and Women's Hospital, Boston, Massachusetts, United States of America, Harvard Medical School, Boston, Massachusetts, United States of America
⨯
Christine Iannaccone,

Affiliations Division of Rheumatology, Immunology, and Allergy, Department of Medicine, Brigham and Women's Hospital, Boston, Massachusetts, United States of America, Harvard Medical School, Boston, Massachusetts, United States of America
⨯
Manuela Cernadas,

Affiliations Department of Pulmonary and Critical Care Medicine, Brigham and Women's Hospital, Boston, Massachusetts, United States of America, Harvard Medical School, Boston, Massachusetts, United States of America
⨯
Michael Weinblatt,

Affiliations Division of Rheumatology, Immunology, and Allergy, Department of Medicine, Brigham and Women's Hospital, Boston, Massachusetts, United States of America, Harvard Medical School, Boston, Massachusetts, United States of America
⨯
Nancy Shadick,

Affiliations Division of Rheumatology, Immunology, and Allergy, Department of Medicine, Brigham and Women's Hospital, Boston, Massachusetts, United States of America, Harvard Medical School, Boston, Massachusetts, United States of America
⨯
Shi-Chuen Miaw,

Affiliation Graduate Institute of Immunology, National Taiwan University College of Medicine, Taipei, Taiwan
⨯
I-Cheng Ho

* E-mail: iho@partners.org

Affiliations Division of Rheumatology, Immunology, and Allergy, Department of Medicine, Brigham and Women's Hospital, Boston, Massachusetts, United States of America, Harvard Medical School, Boston, Massachusetts, United States of America
⨯

PTPN22.6, a Dominant Negative Isoform of PTPN22 and Potential Biomarker of Rheumatoid Arthritis

Hui-Hsin Chang,
Tzong-Shyuan Tai,
Bing Lu,
Christine Iannaccone,
Manuela Cernadas,
Michael Weinblatt,
Nancy Shadick,
Shi-Chuen Miaw,
I-Cheng Ho

Published: March 12, 2012
https://doi.org/10.1371/journal.pone.0033067

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