Placement of Leucine Zipper Motifs at the Carboxyl Terminus of HIV-1 Protease Significantly Reduces Virion Production

Open Access

Peer-reviewed

Research Article

Yen-Yu Pan ,

Contributed equally to this work with: Yen-Yu Pan, Shiu-Mei Wang

Affiliations Department of Medical Research and Education, Taipei Veterans General Hospital, Taipei, Taiwan, Institute of Clinical Medicine, School of Medicine, National Yang-Ming University, Taipei, Taiwan
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Shiu-Mei Wang ,

Contributed equally to this work with: Yen-Yu Pan, Shiu-Mei Wang

Affiliation Institute of Clinical Medicine, School of Medicine, National Yang-Ming University, Taipei, Taiwan
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Kuo-Jung Huang,

Affiliation Department of Medical Research and Education, Taipei Veterans General Hospital, Taipei, Taiwan
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Chien-Cheng Chiang,

Affiliation Institute of Clinical Medicine, School of Medicine, National Yang-Ming University, Taipei, Taiwan
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Chin-Tien Wang

* E-mail: chintien@ym.edu.tw

Affiliations Department of Medical Research and Education, Taipei Veterans General Hospital, Taipei, Taiwan, Institute of Clinical Medicine, School of Medicine, National Yang-Ming University, Taipei, Taiwan
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HIV-1
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Transfection
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293T cells
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Dimers
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Dimerization
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Basic leucine zipper domains
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Substitution mutation
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Virus assembly
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