Enabling Large-Scale Design, Synthesis and Validation of Small Molecule Protein-Protein Antagonists

Open Access

Peer-reviewed

Research Article

David Koes,

Affiliation Department of Computational and Systems Biology, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America
⨯
Kareem Khoury,

Affiliation School of Pharmacy, University of Pittsburgh, Pittsburgh Pennsylvania, United States of America
⨯
Yijun Huang,

Affiliation School of Pharmacy, University of Pittsburgh, Pittsburgh Pennsylvania, United States of America
⨯
Wei Wang,

Affiliation School of Pharmacy, University of Pittsburgh, Pittsburgh Pennsylvania, United States of America
⨯
Michal Bista,

Affiliation Max Planck Institute of Biochemistry, Martinsried, Germany
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Grzegorz M. Popowicz,

Affiliation Max Planck Institute of Biochemistry, Martinsried, Germany
⨯
Siglinde Wolf,

Affiliation Max Planck Institute of Biochemistry, Martinsried, Germany
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Tad A. Holak,

Affiliation Max Planck Institute of Biochemistry, Martinsried, Germany
⨯
Alexander Dömling,

Affiliations Department of Computational and Systems Biology, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America, School of Pharmacy, University of Pittsburgh, Pittsburgh Pennsylvania, United States of America
⨯
Carlos J. Camacho

* E-mail: ccamacho@pitt.edu

Affiliation Department of Computational and Systems Biology, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America
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Library screening
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Chemical synthesis
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Drug screening
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Tryptophan
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Crystal structure
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Drug interactions
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Drug discovery
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Protein-protein interactions
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