Synthesis of a Dual Functional Anti-MDR Tumor Agent PH II-7 with Elucidations of Anti-Tumor Effects and Mechanisms

Ye Su; Xin Cheng; Yaohong Tan; Yunhui Hu; Yuan Zhou; Juanni Liu; Yuanfu Xu; Yinliang Xie; Caiyun Wang; Yingdai Gao; Jianxiang Wang; Tao Cheng; Chunzheng Yang; Dongsheng Xiong; Hua Miao

doi:10.1371/journal.pone.0032782

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Open Access

Peer-reviewed

Research Article

Synthesis of a Dual Functional Anti-MDR Tumor Agent PH II-7 with Elucidations of Anti-Tumor Effects and Mechanisms

Ye Su ,

Contributed equally to this work with: Ye Su, Xin Cheng

Affiliations State Key Laboratory of Experimental Hematology, Department of Pharmacy, Institute of Hematology & Hospital of Blood Diseases, Chinese Academy of Medical Sciences & Peking Union Medical College, Tianjin, People's Republic of China, Matthew Mailing Centre for Translational Transplant Studies, Department of Medicine, University of Western Ontario, Ontario, Canada
⨯
Xin Cheng ,

Contributed equally to this work with: Ye Su, Xin Cheng

Affiliations State Key Laboratory of Experimental Hematology, Department of Pharmacy, Institute of Hematology & Hospital of Blood Diseases, Chinese Academy of Medical Sciences & Peking Union Medical College, Tianjin, People's Republic of China, Laboratory of Molecular Carcinogenesis and Targeted Therapy for Cancer, State Key Laboratory of Biomembrane and Membrane Biotechnology, Institute of Zoology, Chinese Academy of Sciences, Beijing, China
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Yaohong Tan,

Affiliation State Key Laboratory of Experimental Hematology, Department of Pharmacy, Institute of Hematology & Hospital of Blood Diseases, Chinese Academy of Medical Sciences & Peking Union Medical College, Tianjin, People's Republic of China
⨯
Yunhui Hu,

Affiliation State Key Laboratory of Experimental Hematology, Department of Pharmacy, Institute of Hematology & Hospital of Blood Diseases, Chinese Academy of Medical Sciences & Peking Union Medical College, Tianjin, People's Republic of China
⨯
Yuan Zhou,

Affiliation State Key Laboratory of Experimental Hematology, Department of Pharmacy, Institute of Hematology & Hospital of Blood Diseases, Chinese Academy of Medical Sciences & Peking Union Medical College, Tianjin, People's Republic of China
⨯
Juanni Liu,

Affiliation State Key Laboratory of Experimental Hematology, Department of Pharmacy, Institute of Hematology & Hospital of Blood Diseases, Chinese Academy of Medical Sciences & Peking Union Medical College, Tianjin, People's Republic of China
⨯
Yuanfu Xu,

Affiliation State Key Laboratory of Experimental Hematology, Department of Pharmacy, Institute of Hematology & Hospital of Blood Diseases, Chinese Academy of Medical Sciences & Peking Union Medical College, Tianjin, People's Republic of China
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Yinliang Xie,

Affiliation State Key Laboratory of Experimental Hematology, Department of Pharmacy, Institute of Hematology & Hospital of Blood Diseases, Chinese Academy of Medical Sciences & Peking Union Medical College, Tianjin, People's Republic of China
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Caiyun Wang,

Affiliation State Key Laboratory of Experimental Hematology, Department of Pharmacy, Institute of Hematology & Hospital of Blood Diseases, Chinese Academy of Medical Sciences & Peking Union Medical College, Tianjin, People's Republic of China
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Yingdai Gao,

Affiliation State Key Laboratory of Experimental Hematology, Department of Pharmacy, Institute of Hematology & Hospital of Blood Diseases, Chinese Academy of Medical Sciences & Peking Union Medical College, Tianjin, People's Republic of China
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Jianxiang Wang,

Affiliation State Key Laboratory of Experimental Hematology, Department of Pharmacy, Institute of Hematology & Hospital of Blood Diseases, Chinese Academy of Medical Sciences & Peking Union Medical College, Tianjin, People's Republic of China
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Tao Cheng,

Affiliation State Key Laboratory of Experimental Hematology, Department of Pharmacy, Institute of Hematology & Hospital of Blood Diseases, Chinese Academy of Medical Sciences & Peking Union Medical College, Tianjin, People's Republic of China
⨯
Chunzheng Yang,

Affiliation State Key Laboratory of Experimental Hematology, Department of Pharmacy, Institute of Hematology & Hospital of Blood Diseases, Chinese Academy of Medical Sciences & Peking Union Medical College, Tianjin, People's Republic of China
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Dongsheng Xiong ,

* E-mail: dsxiong@ihcams.ac.cn (DX); miaohua00@gmail.com (HM)

Affiliation State Key Laboratory of Experimental Hematology, Department of Pharmacy, Institute of Hematology & Hospital of Blood Diseases, Chinese Academy of Medical Sciences & Peking Union Medical College, Tianjin, People's Republic of China
⨯
Hua Miao

* E-mail: dsxiong@ihcams.ac.cn (DX); miaohua00@gmail.com (HM)

Affiliation Chemical Biology Program, Broad Institute of Harvard and Massachusetts Institute of Technology, Cambridge, Massachusetts, United States of America
⨯

Synthesis of a Dual Functional Anti-MDR Tumor Agent PH II-7 with Elucidations of Anti-Tumor Effects and Mechanisms

Ye Su,
Xin Cheng,
Yaohong Tan,
Yunhui Hu,
Yuan Zhou,
Juanni Liu,
Yuanfu Xu,
Yinliang Xie,
Caiyun Wang,
Yingdai Gao

Published: March 5, 2012
https://doi.org/10.1371/journal.pone.0032782

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