Preventing Phosphorylation of Sterol Regulatory Element-Binding Protein 1a by MAP-Kinases Protects Mice from Fatty Liver and Visceral Obesity

Jorg Kotzka; Birgit Knebel; Jutta Haas; Lorena Kremer; Sylvia Jacob; Sonja Hartwig; Ulrike Nitzgen; Dirk Muller–Wieland

doi:10.1371/journal.pone.0032609

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Peer-reviewed

Research Article

Preventing Phosphorylation of Sterol Regulatory Element-Binding Protein 1a by MAP-Kinases Protects Mice from Fatty Liver and Visceral Obesity

Jorg Kotzka ,

Contributed equally to this work with: Jorg Kotzka, Birgit Knebel

Affiliation Institute of Clinical Biochemistry and Pathobiochemistry, German Diabetes Center at the Heinrich-Heine-University Duesseldorf, Leibniz Center for Diabetes Research, Duesseldorf, Germany
⨯
Birgit Knebel ,

Contributed equally to this work with: Jorg Kotzka, Birgit Knebel

Affiliation Institute of Clinical Biochemistry and Pathobiochemistry, German Diabetes Center at the Heinrich-Heine-University Duesseldorf, Leibniz Center for Diabetes Research, Duesseldorf, Germany
⨯
Jutta Haas,

Affiliation Institute for Diabetes Research, Asklepios Clinic St. Georg, Department of General Internal Medicine, Medical Faculty of Semmelweis University, Hamburg, Germany
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Lorena Kremer,

Affiliation Institute of Clinical Biochemistry and Pathobiochemistry, German Diabetes Center at the Heinrich-Heine-University Duesseldorf, Leibniz Center for Diabetes Research, Duesseldorf, Germany
⨯
Sylvia Jacob,

Affiliation Institute of Clinical Biochemistry and Pathobiochemistry, German Diabetes Center at the Heinrich-Heine-University Duesseldorf, Leibniz Center for Diabetes Research, Duesseldorf, Germany
⨯
Sonja Hartwig,

Affiliation Institute of Clinical Biochemistry and Pathobiochemistry, German Diabetes Center at the Heinrich-Heine-University Duesseldorf, Leibniz Center for Diabetes Research, Duesseldorf, Germany
⨯
Ulrike Nitzgen,

Affiliation Institute of Clinical Biochemistry and Pathobiochemistry, German Diabetes Center at the Heinrich-Heine-University Duesseldorf, Leibniz Center for Diabetes Research, Duesseldorf, Germany
⨯
Dirk Muller–Wieland

* E-mail: d.mueller-wieland@asklepios.com

Affiliation Institute for Diabetes Research, Asklepios Clinic St. Georg, Department of General Internal Medicine, Medical Faculty of Semmelweis University, Hamburg, Germany
⨯

Preventing Phosphorylation of Sterol Regulatory Element-Binding Protein 1a by MAP-Kinases Protects Mice from Fatty Liver and Visceral Obesity

Jorg Kotzka,
Birgit Knebel,
Jutta Haas,
Lorena Kremer,
Sylvia Jacob,
Sonja Hartwig,
Ulrike Nitzgen,
Dirk Muller–Wieland

Published: February 27, 2012
https://doi.org/10.1371/journal.pone.0032609

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Phosphorylation
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Mouse models
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Genetically modified animals
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MAPK signaling cascades
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Fatty liver
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Insulin
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Lipids
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