M3 Subtype of Muscarinic Acetylcholine Receptor Promotes Cardioprotection via the Suppression of miR-376b-5p

Zhenyu Pan; Yueping Guo; Hanping Qi; Kai Fan; Shu Wang; Hua Zhao; Yuhua Fan; Jing Xie; Feng Guo; Yunlong Hou; Ning Wang; Rong Huo; Yong Zhang; Yan Liu; Zhimin Du

doi:10.1371/journal.pone.0032571

Loading metrics

Open Access

Peer-reviewed

Research Article

M₃ Subtype of Muscarinic Acetylcholine Receptor Promotes Cardioprotection via the Suppression of miR-376b-5p

Zhenyu Pan ,

Contributed equally to this work with: Zhenyu Pan, Yueping Guo

Affiliation Department of Pharmacology, the State-Province Key Laboratories of Biomedicine-Pharmaceutics of China, Key Laboratory of Cardiovascular Research, Ministry of Education, Harbin Medical University, Harbin, Heilongjiang, People′s Republic of China
⨯
Yueping Guo ,

Contributed equally to this work with: Zhenyu Pan, Yueping Guo

Affiliation Department of Anesthesiology of the Second Affiliated Hospital, Harbin Medical University, Harbin, Heilongjiang, People′s Republic of China
⨯
Hanping Qi,

Affiliation Department of Pharmacology, the State-Province Key Laboratories of Biomedicine-Pharmaceutics of China, Key Laboratory of Cardiovascular Research, Ministry of Education, Harbin Medical University, Harbin, Heilongjiang, People′s Republic of China
⨯
Kai Fan,

Affiliation Department of Pharmacology, the State-Province Key Laboratories of Biomedicine-Pharmaceutics of China, Key Laboratory of Cardiovascular Research, Ministry of Education, Harbin Medical University, Harbin, Heilongjiang, People′s Republic of China
⨯
Shu Wang,

Affiliation Department of Pharmacology, the State-Province Key Laboratories of Biomedicine-Pharmaceutics of China, Key Laboratory of Cardiovascular Research, Ministry of Education, Harbin Medical University, Harbin, Heilongjiang, People′s Republic of China
⨯
Hua Zhao,

Affiliation Department of Pharmacology, the State-Province Key Laboratories of Biomedicine-Pharmaceutics of China, Key Laboratory of Cardiovascular Research, Ministry of Education, Harbin Medical University, Harbin, Heilongjiang, People′s Republic of China
⨯
Yuhua Fan,

Affiliation Institute of Clinical Pharmacology of the Second Affiliated Hospital, Harbin Medical University, Harbin, Heilongjiang, People′s Republic of China
⨯
Jing Xie,

Affiliation Department of Pharmacology, the State-Province Key Laboratories of Biomedicine-Pharmaceutics of China, Key Laboratory of Cardiovascular Research, Ministry of Education, Harbin Medical University, Harbin, Heilongjiang, People′s Republic of China
⨯
Feng Guo,

Affiliation Department of Pharmacology, the State-Province Key Laboratories of Biomedicine-Pharmaceutics of China, Key Laboratory of Cardiovascular Research, Ministry of Education, Harbin Medical University, Harbin, Heilongjiang, People′s Republic of China
⨯
Yunlong Hou,

Affiliation Department of Pharmacology, the State-Province Key Laboratories of Biomedicine-Pharmaceutics of China, Key Laboratory of Cardiovascular Research, Ministry of Education, Harbin Medical University, Harbin, Heilongjiang, People′s Republic of China
⨯
Ning Wang,

Affiliation Department of Pharmacology, the State-Province Key Laboratories of Biomedicine-Pharmaceutics of China, Key Laboratory of Cardiovascular Research, Ministry of Education, Harbin Medical University, Harbin, Heilongjiang, People′s Republic of China
⨯
Rong Huo,

Affiliation Department of Pharmacology, the State-Province Key Laboratories of Biomedicine-Pharmaceutics of China, Key Laboratory of Cardiovascular Research, Ministry of Education, Harbin Medical University, Harbin, Heilongjiang, People′s Republic of China
⨯
Yong Zhang,

Affiliation Department of Pharmacology, the State-Province Key Laboratories of Biomedicine-Pharmaceutics of China, Key Laboratory of Cardiovascular Research, Ministry of Education, Harbin Medical University, Harbin, Heilongjiang, People′s Republic of China
⨯
Yan Liu ,

* E-mail: liuyangy2000@yahoo.com.cn (YL); dzm1956@126.com (ZD)

Affiliation Department of Pharmacology, the State-Province Key Laboratories of Biomedicine-Pharmaceutics of China, Key Laboratory of Cardiovascular Research, Ministry of Education, Harbin Medical University, Harbin, Heilongjiang, People′s Republic of China
⨯
Zhimin Du

* E-mail: liuyangy2000@yahoo.com.cn (YL); dzm1956@126.com (ZD)

Affiliation Institute of Clinical Pharmacology of the Second Affiliated Hospital, Harbin Medical University, Harbin, Heilongjiang, People′s Republic of China
⨯

M₃ Subtype of Muscarinic Acetylcholine Receptor Promotes Cardioprotection via the Suppression of miR-376b-5p

Zhenyu Pan,
Yueping Guo,
Hanping Qi,
Kai Fan,
Shu Wang,
Hua Zhao,
Yuhua Fan,
Jing Xie,
Feng Guo,
Yunlong Hou

Published: March 2, 2012
https://doi.org/10.1371/journal.pone.0032571

Reader Comments (0)

Post a new comment on this article

Subject Areas
?

For more information about PLOS Subject Areas, click here.
We want your feedback. Do these Subject Areas make sense for this article? Click the target next to the incorrect Subject Area and let us know. Thanks for your help!

Ischemia
Is the Subject Area "Ischemia" applicable to this article?

Thanks for your feedback.
Transcription factors
Is the Subject Area "Transcription factors" applicable to this article?

Thanks for your feedback.
MicroRNAs
Is the Subject Area "MicroRNAs" applicable to this article?

Thanks for your feedback.
Cholines
Is the Subject Area "Cholines" applicable to this article?

Thanks for your feedback.
Transfection
Is the Subject Area "Transfection" applicable to this article?

Thanks for your feedback.
Microarrays
Is the Subject Area "Microarrays" applicable to this article?

Thanks for your feedback.
Reactive oxygen species
Is the Subject Area "Reactive oxygen species" applicable to this article?

Thanks for your feedback.
Luciferase
Is the Subject Area "Luciferase" applicable to this article?

Thanks for your feedback.