[11C]flumazenil Binding Is Increased in a Dose-Dependent Manner with Tiagabine-Induced Elevations in GABA Levels

W. Gordon Frankle; Raymond Y. Cho; N. Scott Mason; Chi-Min Chen; Michael Himes; Christopher Walker; David A. Lewis; Chester A. Mathis; Rajesh Narendran

doi:10.1371/journal.pone.0032443

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Peer-reviewed

Research Article

[¹¹C]flumazenil Binding Is Increased in a Dose-Dependent Manner with Tiagabine-Induced Elevations in GABA Levels

W. Gordon Frankle ,

* E-mail: franklewg@upmc.edu

Affiliations Department of Psychiatry, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America, Department of Radiology, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America
⨯
Raymond Y. Cho,

Affiliation Department of Psychiatry, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America
⨯
N. Scott Mason,

Affiliation Department of Radiology, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America
⨯
Chi-Min Chen,

Affiliation Department of Psychiatry, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America
⨯
Michael Himes,

Affiliation Department of Psychiatry, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America
⨯
Christopher Walker,

Affiliation Department of Psychiatry, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America
⨯
David A. Lewis,

Affiliations Department of Psychiatry, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America, Department of Neuroscience, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America
⨯
Chester A. Mathis,

Affiliation Department of Radiology, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America
⨯
Rajesh Narendran

Affiliations Department of Psychiatry, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America, Department of Radiology, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America
⨯

[¹¹C]flumazenil Binding Is Increased in a Dose-Dependent Manner with Tiagabine-Induced Elevations in GABA Levels

W. Gordon Frankle,
Raymond Y. Cho,
N. Scott Mason,
Chi-Min Chen,
Michael Himes,
Christopher Walker,
David A. Lewis,
Chester A. Mathis,
Rajesh Narendran

Published: February 27, 2012
https://doi.org/10.1371/journal.pone.0032443

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