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Open Access
Peer-reviewed
Research Article
Conditionally Immortalized Mouse Embryonic Fibroblasts Retain Proliferative Activity without Compromising Multipotent Differentiation Potential
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Enyi Huang,
Affiliations School of Bioengineering, Chongqing University, Chongqing, China, Molecular Oncology Laboratory, Department of Surgery, The University of Chicago Medical Center, Chicago, Illinois, United States of America
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Yang Bi,
Affiliations Molecular Oncology Laboratory, Department of Surgery, The University of Chicago Medical Center, Chicago, Illinois, United States of America, Stem Cell Biology and Therapy Laboratory of the Key Laboratory for Pediatrics co-designated by Chinese Ministry of Education and Chongqing Bureau of Education, The Children's Hospital of Chongqing Medical University, Chongqing, China
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Wei Jiang,
Affiliation Molecular Oncology Laboratory, Department of Surgery, The University of Chicago Medical Center, Chicago, Illinois, United States of America
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Xiaoji Luo,
Affiliations Molecular Oncology Laboratory, Department of Surgery, The University of Chicago Medical Center, Chicago, Illinois, United States of America, Key Laboratory of Diagnostic Medicine designated by the Chinese Ministry of Education, and the Affiliated Hospitals of Chongqing Medical University, Chongqing, China
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Ke Yang,
Affiliations Molecular Oncology Laboratory, Department of Surgery, The University of Chicago Medical Center, Chicago, Illinois, United States of America, Department of Cell Biology, Third Military Medical University, Chongqing, China
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Jian-Li Gao,
Affiliations Molecular Oncology Laboratory, Department of Surgery, The University of Chicago Medical Center, Chicago, Illinois, United States of America, Institute of Materia Medica, Zhejiang Chinese Medical University, Hangzhou, China
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Yanhong Gao,
Affiliations Molecular Oncology Laboratory, Department of Surgery, The University of Chicago Medical Center, Chicago, Illinois, United States of America, Department of Geriatrics, Xinhua Hospital of Shanghai Jiatong University, Shanghai, China
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Qing Luo,
Affiliations Molecular Oncology Laboratory, Department of Surgery, The University of Chicago Medical Center, Chicago, Illinois, United States of America, Stem Cell Biology and Therapy Laboratory of the Key Laboratory for Pediatrics co-designated by Chinese Ministry of Education and Chongqing Bureau of Education, The Children's Hospital of Chongqing Medical University, Chongqing, China
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Qiong Shi,
Affiliations Molecular Oncology Laboratory, Department of Surgery, The University of Chicago Medical Center, Chicago, Illinois, United States of America, Key Laboratory of Diagnostic Medicine designated by the Chinese Ministry of Education, and the Affiliated Hospitals of Chongqing Medical University, Chongqing, China
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Stephanie H. Kim,
Affiliation Molecular Oncology Laboratory, Department of Surgery, The University of Chicago Medical Center, Chicago, Illinois, United States of America
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Xing Liu,
Affiliations Molecular Oncology Laboratory, Department of Surgery, The University of Chicago Medical Center, Chicago, Illinois, United States of America, Stem Cell Biology and Therapy Laboratory of the Key Laboratory for Pediatrics co-designated by Chinese Ministry of Education and Chongqing Bureau of Education, The Children's Hospital of Chongqing Medical University, Chongqing, China
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Mi Li,
Affiliations Molecular Oncology Laboratory, Department of Surgery, The University of Chicago Medical Center, Chicago, Illinois, United States of America, Stem Cell Biology and Therapy Laboratory of the Key Laboratory for Pediatrics co-designated by Chinese Ministry of Education and Chongqing Bureau of Education, The Children's Hospital of Chongqing Medical University, Chongqing, China
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Ning Hu,
Affiliations Molecular Oncology Laboratory, Department of Surgery, The University of Chicago Medical Center, Chicago, Illinois, United States of America, Key Laboratory of Diagnostic Medicine designated by the Chinese Ministry of Education, and the Affiliated Hospitals of Chongqing Medical University, Chongqing, China
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Hong Liu,
Affiliations Molecular Oncology Laboratory, Department of Surgery, The University of Chicago Medical Center, Chicago, Illinois, United States of America, Key Laboratory of Diagnostic Medicine designated by the Chinese Ministry of Education, and the Affiliated Hospitals of Chongqing Medical University, Chongqing, China
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Jing Cui,
Affiliations Molecular Oncology Laboratory, Department of Surgery, The University of Chicago Medical Center, Chicago, Illinois, United States of America, Key Laboratory of Diagnostic Medicine designated by the Chinese Ministry of Education, and the Affiliated Hospitals of Chongqing Medical University, Chongqing, China
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Wenwen Zhang,
Affiliations Molecular Oncology Laboratory, Department of Surgery, The University of Chicago Medical Center, Chicago, Illinois, United States of America, Key Laboratory of Diagnostic Medicine designated by the Chinese Ministry of Education, and the Affiliated Hospitals of Chongqing Medical University, Chongqing, China
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Ruidong Li,
Affiliations Molecular Oncology Laboratory, Department of Surgery, The University of Chicago Medical Center, Chicago, Illinois, United States of America, Key Laboratory of Diagnostic Medicine designated by the Chinese Ministry of Education, and the Affiliated Hospitals of Chongqing Medical University, Chongqing, China
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Xiang Chen,
Affiliations Molecular Oncology Laboratory, Department of Surgery, The University of Chicago Medical Center, Chicago, Illinois, United States of America, Department of Orthopaedic Surgery, The Affiliated Tangdu Hospital, Fourth Military Medical University, Xi'an, China
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Jikun Shen,
Affiliation Molecular Oncology Laboratory, Department of Surgery, The University of Chicago Medical Center, Chicago, Illinois, United States of America
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Yuhan Kong,
Affiliations Molecular Oncology Laboratory, Department of Surgery, The University of Chicago Medical Center, Chicago, Illinois, United States of America, Key Laboratory of Diagnostic Medicine designated by the Chinese Ministry of Education, and the Affiliated Hospitals of Chongqing Medical University, Chongqing, China
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Jiye Zhang,
Affiliations Molecular Oncology Laboratory, Department of Surgery, The University of Chicago Medical Center, Chicago, Illinois, United States of America, Key Laboratory of Diagnostic Medicine designated by the Chinese Ministry of Education, and the Affiliated Hospitals of Chongqing Medical University, Chongqing, China
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Jinhua Wang,
Affiliations Molecular Oncology Laboratory, Department of Surgery, The University of Chicago Medical Center, Chicago, Illinois, United States of America, Key Laboratory of Diagnostic Medicine designated by the Chinese Ministry of Education, and the Affiliated Hospitals of Chongqing Medical University, Chongqing, China
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Jinyong Luo,
Affiliations Molecular Oncology Laboratory, Department of Surgery, The University of Chicago Medical Center, Chicago, Illinois, United States of America, Key Laboratory of Diagnostic Medicine designated by the Chinese Ministry of Education, and the Affiliated Hospitals of Chongqing Medical University, Chongqing, China
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Bai-Cheng He,
Affiliations Molecular Oncology Laboratory, Department of Surgery, The University of Chicago Medical Center, Chicago, Illinois, United States of America, Key Laboratory of Diagnostic Medicine designated by the Chinese Ministry of Education, and the Affiliated Hospitals of Chongqing Medical University, Chongqing, China
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Huicong Wang,
Affiliation School of Bioengineering, Chongqing University, Chongqing, China
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Russell R. Reid,
Affiliation Molecular Oncology Laboratory, Department of Surgery, The University of Chicago Medical Center, Chicago, Illinois, United States of America
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Hue H. Luu,
Affiliation Molecular Oncology Laboratory, Department of Surgery, The University of Chicago Medical Center, Chicago, Illinois, United States of America
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Rex C. Haydon,
Affiliation Molecular Oncology Laboratory, Department of Surgery, The University of Chicago Medical Center, Chicago, Illinois, United States of America
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Li Yang ,
* E-mail: tche@surgery.bsd.uchicago.edu (T-CH); yangli@cqu.edu.cn (LY)
Affiliation School of Bioengineering, Chongqing University, Chongqing, China
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Tong-Chuan He
* E-mail: tche@surgery.bsd.uchicago.edu (T-CH); yangli@cqu.edu.cn (LY)
Affiliations Molecular Oncology Laboratory, Department of Surgery, The University of Chicago Medical Center, Chicago, Illinois, United States of America, Stem Cell Biology and Therapy Laboratory of the Key Laboratory for Pediatrics co-designated by Chinese Ministry of Education and Chongqing Bureau of Education, The Children's Hospital of Chongqing Medical University, Chongqing, China, Key Laboratory of Diagnostic Medicine designated by the Chinese Ministry of Education, and the Affiliated Hospitals of Chongqing Medical University, Chongqing, China
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Conditionally Immortalized Mouse Embryonic Fibroblasts Retain Proliferative Activity without Compromising Multipotent Differentiation Potential
- Enyi Huang,
- Yang Bi,
- Wei Jiang,
- Xiaoji Luo,
- Ke Yang,
- Jian-Li Gao,
- Yanhong Gao,
- Qing Luo,
- Qiong Shi,
- Stephanie H. Kim
- Published: February 23, 2012
- https://doi.org/10.1371/journal.pone.0032428