The Mucin MUC4 and Its Membrane Partner ErbB2 Regulate Biological Properties of Human CAPAN-2 Pancreatic Cancer Cells via Different Signalling Pathways

Nicolas Jonckheere; Nicolas Skrypek; Johann Merlin; Anne Frédérique Dessein; Patrick Dumont; Emmanuelle Leteurtre; Ann Harris; Jean-Luc Desseyn; Christiane Susini; Frédéric Frénois; Isabelle Van Seuningen

doi:10.1371/journal.pone.0032232

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Open Access

Peer-reviewed

Research Article

The Mucin MUC4 and Its Membrane Partner ErbB2 Regulate Biological Properties of Human CAPAN-2 Pancreatic Cancer Cells via Different Signalling Pathways

Nicolas Jonckheere ,

* E-mail: nicolas.jonckheere@inserm.fr

Affiliations Inserm, UMR837, Jean Pierre Aubert Research Center, Team #5 “Mucins, epithelial differentiation and carcinogenesis”, Lille, France, Université Lille Nord de France, Lille, France
⨯
Nicolas Skrypek,

Affiliations Inserm, UMR837, Jean Pierre Aubert Research Center, Team #5 “Mucins, epithelial differentiation and carcinogenesis”, Lille, France, Université Lille Nord de France, Lille, France
⨯
Johann Merlin,

Affiliations Inserm, UMR837, Jean Pierre Aubert Research Center, Team #5 “Mucins, epithelial differentiation and carcinogenesis”, Lille, France, Université Lille Nord de France, Lille, France
⨯
Anne Frédérique Dessein,

Affiliations Inserm, UMR837, Jean Pierre Aubert Research Center, Team #5 “Mucins, epithelial differentiation and carcinogenesis”, Lille, France, Université Lille Nord de France, Lille, France
⨯
Patrick Dumont,

Affiliation CNRS UMR8161, Institut de Biologie de Lille, Lille, France
⨯
Emmanuelle Leteurtre,

Affiliations Inserm, UMR837, Jean Pierre Aubert Research Center, Team #5 “Mucins, epithelial differentiation and carcinogenesis”, Lille, France, Université Lille Nord de France, Lille, France, Centre de Biologie-Pathologie, Centre Hospitalier Régional et Universitaire de Lille, Lille, France
⨯
Ann Harris,

Affiliation Human Molecular Genetics Program, Children's Memorial Research Center, and Department of Pediatrics. Northwestern University, Chicago, Illinois, United States of America
⨯
Jean-Luc Desseyn,

Affiliations Université Lille Nord de France, Lille, France, Inserm U995, Lille, France
⨯
Christiane Susini,

Affiliation Inserm, U858, Institut de Médecine Moléculaire de Rangueil, BP84225, Toulouse, France
⨯
Frédéric Frénois,

Affiliations Inserm, UMR837, Jean Pierre Aubert Research Center, Team #5 “Mucins, epithelial differentiation and carcinogenesis”, Lille, France, Université Lille Nord de France, Lille, France
⨯
Isabelle Van Seuningen

Affiliations Inserm, UMR837, Jean Pierre Aubert Research Center, Team #5 “Mucins, epithelial differentiation and carcinogenesis”, Lille, France, Université Lille Nord de France, Lille, France
⨯

The Mucin MUC4 and Its Membrane Partner ErbB2 Regulate Biological Properties of Human CAPAN-2 Pancreatic Cancer Cells via Different Signalling Pathways

Nicolas Jonckheere,
Nicolas Skrypek,
Johann Merlin,
Anne Frédérique Dessein,
Patrick Dumont,
Emmanuelle Leteurtre,
Ann Harris,
Jean-Luc Desseyn,
Christiane Susini,
Frédéric Frénois

Published: February 29, 2012
https://doi.org/10.1371/journal.pone.0032232

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