Common Variants in the Type 2 Diabetes KCNQ1 Gene Are Associated with Impairments in Insulin Secretion During Hyperglycaemic Glucose Clamp

• Jana V. van Vliet-Ostaptchouk ,

  * E-mail: j.v.van.vliet@umcg.nl

  Affiliations Molecular Genetics, Department of Pathology and Medical Biology, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands, Department of Endocrinology, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands, Department of Epidemiology, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands

  ⨯
• Timon W. van Haeften,

  Affiliation Department of Internal Medicine, University Medical Centre Utrecht, Utrecht, the Netherlands

  ⨯
• Gijs W. D. Landman,

  Affiliation Diabetes Centre, Isala Clinics, Zwolle, the Netherlands

  ⨯
• Erwin Reiling,

  Affiliation Department of Molecular Cell Biology, Leiden University Medical Centre, Leiden, the Netherlands

  ⨯
• Nanne Kleefstra,

  Affiliations Diabetes Centre, Isala Clinics, Zwolle, the Netherlands, Department of Internal Medicine, University Medical Center Groningen and University of Groningen, the Netherlands, Medical Research Group, Langerhans, Zwolle, the Netherlands

  ⨯
• Henk J. G. Bilo,

  Affiliations Diabetes Centre, Isala Clinics, Zwolle, the Netherlands, Department of Internal Medicine, University Medical Center Groningen and University of Groningen, the Netherlands

  ⨯
• Olaf H. Klungel,

  Affiliation Division of Pharmacoepidemiology & Clinical Pharmacology, Utrecht Institute for Pharmaceutical Sciences, University of Utrecht, Utrecht, the Netherlands

  ⨯
• Anthonius de Boer,

  Affiliation Division of Pharmacoepidemiology & Clinical Pharmacology, Utrecht Institute for Pharmaceutical Sciences, University of Utrecht, Utrecht, the Netherlands

  ⨯
• Cleo C. van Diemen,

  Affiliation Department of Genetics, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands

  ⨯
• Cisca Wijmenga,

  Affiliation Department of Genetics, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands

  ⨯
• H. Marike Boezen,

  Affiliation Department of Epidemiology, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands

  ⨯
• Jacqueline M. Dekker,

  Affiliations EMGO+ Institute for Health and Care Research, VU University Medical Centre, Amsterdam, the Netherlands, Department of Epidemiology and Biostatistics, VU University Medical Centre, Amsterdam, the Netherlands

  ⨯
• Esther van 't Riet,

  Affiliations EMGO+ Institute for Health and Care Research, VU University Medical Centre, Amsterdam, the Netherlands, Department of Epidemiology and Biostatistics, VU University Medical Centre, Amsterdam, the Netherlands

  ⨯
• Giel Nijpels,

  Affiliations EMGO+ Institute for Health and Care Research, VU University Medical Centre, Amsterdam, the Netherlands, Department of General Practice, VU University Medical Centre, Amsterdam, the Netherlands

  ⨯
• Laura M. C. Welschen,

  Affiliations EMGO+ Institute for Health and Care Research, VU University Medical Centre, Amsterdam, the Netherlands, Department of General Practice, VU University Medical Centre, Amsterdam, the Netherlands

  ⨯
• Hata Zavrelova,

  Affiliations EMGO+ Institute for Health and Care Research, VU University Medical Centre, Amsterdam, the Netherlands, Department of Ophthalmology, VU University Medical Center, Amsterdam, the Netherlands

  ⨯
• Elinda J. Bruin,

  Affiliation Molecular Genetics, Department of Pathology and Medical Biology, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands

  ⨯
• Clara C. Elbers,

  Affiliations Department of Medical Genetics (DBG) University Medical Center Utrecht, Utrecht, the Netherlands, Julius Centre for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, the Netherlands

  ⨯
• Florianne Bauer,

  Affiliations Department of Medical Genetics (DBG) University Medical Center Utrecht, Utrecht, the Netherlands, Julius Centre for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, the Netherlands

  ⨯
• N. Charlotte Onland-Moret,

  Affiliations Department of Medical Genetics (DBG) University Medical Center Utrecht, Utrecht, the Netherlands, Julius Centre for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, the Netherlands

  ⨯
• Yvonne T. van der Schouw,

  Affiliation Julius Centre for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, the Netherlands

  ⨯
• Diederick E. Grobbee,

  Affiliation Julius Centre for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, the Netherlands

  ⨯
• Annemieke M. W. Spijkerman,

  Affiliation National Institute for Public Health and the Environment (RIVM), Bilthoven, the Netherlands

  ⨯
• Daphne L. van der A,

  Affiliation National Institute for Public Health and the Environment (RIVM), Bilthoven, the Netherlands

  ⨯
• Annemarie M. Simonis-Bik,

  Affiliation Diabetes Center, VU University Medical Center, Amsterdam, the Netherlands

  ⨯
• Elisabeth M. W. Eekhoff,

  Affiliation Diabetes Center, VU University Medical Center, Amsterdam, the Netherlands

  ⨯
• Michaela Diamant,

  Affiliation Diabetes Center, VU University Medical Center, Amsterdam, the Netherlands

  ⨯
• Mark H. H. Kramer,

  Affiliation Diabetes Center, VU University Medical Center, Amsterdam, the Netherlands

  ⨯
• Dorret I. Boomsma,

  Affiliations Department of Biological Psychology, VU University, Amsterdam, the Netherlands, EMGO+ Institute for Health and Care Research, VU University Medical Centre, Amsterdam, the Netherlands

  ⨯
• Eco J. de Geus,

  Affiliations Department of Biological Psychology, VU University, Amsterdam, the Netherlands, EMGO+ Institute for Health and Care Research, VU University Medical Centre, Amsterdam, the Netherlands

  ⨯
• Gonneke Willemsen,

  Affiliations Department of Biological Psychology, VU University, Amsterdam, the Netherlands, EMGO+ Institute for Health and Care Research, VU University Medical Centre, Amsterdam, the Netherlands

  ⨯
• P. Eline Slagboom,

  Affiliations Department of Medical Statistics and Bioinformatics, section Molecular Epidemiology, Leiden University Medical Center, Leiden, the Netherlands, Netherlands Consortium for Healthy Aging, the Netherlands

  ⨯
• Marten H. Hofker ,

  Contributed equally to this work with: Marten H. Hofker, Leen M. 't Hart

  Affiliation Molecular Genetics, Department of Pathology and Medical Biology, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands

  ⨯
•  [ ... ],
• Leen M. 't Hart

  Contributed equally to this work with: Marten H. Hofker, Leen M. 't Hart

  Affiliations Diabetes Centre, Isala Clinics, Zwolle, the Netherlands, Department of Medical Statistics and Bioinformatics, section Molecular Epidemiology, Leiden University Medical Center, Leiden, the Netherlands

  ⨯
• [ view all ]
• [ view less ]