A Stochastic Step Model of Replicative Senescence Explains ROS Production Rate in Ageing Cell Populations

Conor Lawless; Diana Jurk; Colin S. Gillespie; Daryl Shanley; Gabriele Saretzki; Thomas von Zglinicki; João F. Passos

doi:10.1371/journal.pone.0032117

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Peer-reviewed

Research Article

A Stochastic Step Model of Replicative Senescence Explains ROS Production Rate in Ageing Cell Populations

Conor Lawless,

Affiliations Institute for Cell and Molecular Biosciences, Newcastle University, Newcastle-upon-Tyne, United Kingdom, Centre for Integrated Systems Biology of Ageing and Nutrition, Newcastle University, Newcastle-upon-Tyne, United Kingdom
⨯
Diana Jurk,

Affiliations Centre for Integrated Systems Biology of Ageing and Nutrition, Newcastle University, Newcastle-upon-Tyne, United Kingdom, Institute for Ageing and Health, Newcastle University, Newcastle-upon-Tyne, United Kingdom
⨯
Colin S. Gillespie,

Affiliations Centre for Integrated Systems Biology of Ageing and Nutrition, Newcastle University, Newcastle-upon-Tyne, United Kingdom, School of Mathematics & Statistics, Newcastle University, Newcastle-upon-Tyne, United Kingdom
⨯
Daryl Shanley,

Affiliations Centre for Integrated Systems Biology of Ageing and Nutrition, Newcastle University, Newcastle-upon-Tyne, United Kingdom, Institute for Ageing and Health, Newcastle University, Newcastle-upon-Tyne, United Kingdom
⨯
Gabriele Saretzki,

Affiliations Centre for Integrated Systems Biology of Ageing and Nutrition, Newcastle University, Newcastle-upon-Tyne, United Kingdom, Institute for Ageing and Health, Newcastle University, Newcastle-upon-Tyne, United Kingdom
⨯
Thomas von Zglinicki,

Affiliations Centre for Integrated Systems Biology of Ageing and Nutrition, Newcastle University, Newcastle-upon-Tyne, United Kingdom, Institute for Ageing and Health, Newcastle University, Newcastle-upon-Tyne, United Kingdom
⨯
João F. Passos

* E-mail: Joao.Passos@ncl.ac.uk

Affiliations Centre for Integrated Systems Biology of Ageing and Nutrition, Newcastle University, Newcastle-upon-Tyne, United Kingdom, Institute for Ageing and Health, Newcastle University, Newcastle-upon-Tyne, United Kingdom
⨯

A Stochastic Step Model of Replicative Senescence Explains ROS Production Rate in Ageing Cell Populations

Conor Lawless,
Diana Jurk,
Colin S. Gillespie,
Daryl Shanley,
Gabriele Saretzki,
Thomas von Zglinicki,
João F. Passos

Published: February 16, 2012
https://doi.org/10.1371/journal.pone.0032117

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