A Latent Variable Partial Least Squares Path Modeling Approach to Regional Association and Polygenic Effect with Applications to a Human Obesity Study

• Fuzhong Xue,

  Affiliations Department of Epidemiology and Health Statistics, School of Public Health, Shandong University, Jinan, China, MRC Epidemiology Unit and Institute of Metabolic Science, Cambridge, United Kingdom

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• Shengxu Li,

  Affiliation Department of Epidemiology, School of Public Health and Tropical Medicine, Tulane University, New Orleans, Louisiana, United States of America

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• Jian'an Luan,

  Affiliation MRC Epidemiology Unit and Institute of Metabolic Science, Cambridge, United Kingdom

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• Zhongshang Yuan,

  Affiliation Department of Epidemiology and Health Statistics, School of Public Health, Shandong University, Jinan, China

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• Robert N. Luben,

  Affiliation Strangeways Research Laboratory, Department of Public Health and Primary Care, University of Cambridge, Cambridge, United Kingdom

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• Kay-Tee Khaw,

  Affiliation Clinical Gerontology Unit, School of Clinical Medicine, University of Cambridge, Cambridge, United Kingdom

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• Nicholas J. Wareham,

  Affiliation MRC Epidemiology Unit and Institute of Metabolic Science, Cambridge, United Kingdom

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• Ruth J. F. Loos,

  Affiliation MRC Epidemiology Unit and Institute of Metabolic Science, Cambridge, United Kingdom

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• Jing Hua Zhao

  * E-mail: jinghua.zhao@mrc-epid.cam.ac.uk

  Affiliation MRC Epidemiology Unit and Institute of Metabolic Science, Cambridge, United Kingdom

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