Tacrine-6-Ferulic Acid, a Novel Multifunctional Dimer, Inhibits Amyloid-β-Mediated Alzheimer's Disease-Associated Pathogenesis In Vitro and In Vivo

Rongbiao Pi; Xuexuan Mao; Xiaojuan Chao; Zhiyi Cheng; Mengfei Liu; Xiaolu Duan; Mingzhong Ye; Xiaohong Chen; Zhengrong Mei; Peiqing Liu; Wenming Li; Yifan Han

doi:10.1371/journal.pone.0031921

Loading metrics

Open Access

Peer-reviewed

Research Article

Tacrine-6-Ferulic Acid, a Novel Multifunctional Dimer, Inhibits Amyloid-β-Mediated Alzheimer's Disease-Associated Pathogenesis In Vitro and In Vivo

Rongbiao Pi ,

* E-mail: pirb@mail.sysu.edu.cn (RP); bcwmli@pharm.emory.edu (WL); bcyfhan@inet.polyu.edu.hk (YH)

Affiliation Department of Pharmacology and Toxicology, School of Pharmaceutical Sciences, Sun Yat-Sen University, Guangzhou, China
⨯
Xuexuan Mao,

Current address: Department of Neuronal Plasticity, School of Medicine, Tsinghua University, Beijing, China.

Affiliation Department of Pharmacology and Toxicology, School of Pharmaceutical Sciences, Sun Yat-Sen University, Guangzhou, China
⨯
Xiaojuan Chao,

Affiliation Department of Pharmacology and Toxicology, School of Pharmaceutical Sciences, Sun Yat-Sen University, Guangzhou, China
⨯
Zhiyi Cheng,

Affiliation Department of Pharmacology and Toxicology, School of Pharmaceutical Sciences, Sun Yat-Sen University, Guangzhou, China
⨯
Mengfei Liu,

Affiliation Department of Pharmacology and Toxicology, School of Pharmaceutical Sciences, Sun Yat-Sen University, Guangzhou, China
⨯
Xiaolu Duan,

Affiliation Department of Pharmacology and Toxicology, School of Pharmaceutical Sciences, Sun Yat-Sen University, Guangzhou, China
⨯
Mingzhong Ye,

Affiliation Department of Pharmacology and Toxicology, School of Pharmaceutical Sciences, Sun Yat-Sen University, Guangzhou, China
⨯
Xiaohong Chen,

Affiliation Department of Neurology, The Third Affiliated Hospital, Sun Yat-Sen University, Guangzhou, China
⨯
Zhengrong Mei,

Affiliation Department of Pharmacology and Toxicology, School of Pharmaceutical Sciences, Sun Yat-Sen University, Guangzhou, China
⨯
Peiqing Liu,

Affiliation Department of Pharmacology and Toxicology, School of Pharmaceutical Sciences, Sun Yat-Sen University, Guangzhou, China
⨯
Wenming Li ,

* E-mail: pirb@mail.sysu.edu.cn (RP); bcwmli@pharm.emory.edu (WL); bcyfhan@inet.polyu.edu.hk (YH)

Affiliations Department of Applied Biology and Chemical Technology, Institute of Modern Chinese Medicine, The Hong Kong Polytechnic University, Hong Kong, China, Department of Pharmacology and Neurology, School of Medicine, Emory University, Atlanta, Georgia, United States of America
⨯
Yifan Han

* E-mail: pirb@mail.sysu.edu.cn (RP); bcwmli@pharm.emory.edu (WL); bcyfhan@inet.polyu.edu.hk (YH)

Affiliation Department of Applied Biology and Chemical Technology, Institute of Modern Chinese Medicine, The Hong Kong Polytechnic University, Hong Kong, China
⨯

Tacrine-6-Ferulic Acid, a Novel Multifunctional Dimer, Inhibits Amyloid-β-Mediated Alzheimer's Disease-Associated Pathogenesis In Vitro and In Vivo

Rongbiao Pi,
Xuexuan Mao,
Xiaojuan Chao,
Zhiyi Cheng,
Mengfei Liu,
Xiaolu Duan,
Mingzhong Ye,
Xiaohong Chen,
Zhengrong Mei,
Peiqing Liu

Published: February 23, 2012
https://doi.org/10.1371/journal.pone.0031921

Reader Comments (0)

Post a new comment on this article

Subject Areas
?

For more information about PLOS Subject Areas, click here.
We want your feedback. Do these Subject Areas make sense for this article? Click the target next to the incorrect Subject Area and let us know. Thanks for your help!

Alzheimer's disease
Is the Subject Area "Alzheimer's disease" applicable to this article?

Thanks for your feedback.
Oxidative stress
Is the Subject Area "Oxidative stress" applicable to this article?

Thanks for your feedback.
Cognitive impairment
Is the Subject Area "Cognitive impairment" applicable to this article?

Thanks for your feedback.
Cell death
Is the Subject Area "Cell death" applicable to this article?

Thanks for your feedback.
Neuronal death
Is the Subject Area "Neuronal death" applicable to this article?

Thanks for your feedback.
Superoxide dismutase
Is the Subject Area "Superoxide dismutase" applicable to this article?

Thanks for your feedback.
Cholinergics
Is the Subject Area "Cholinergics" applicable to this article?

Thanks for your feedback.
Mouse models
Is the Subject Area "Mouse models" applicable to this article?

Thanks for your feedback.