Liver-Specific Expression of Transcriptionally Active SREBP-1c Is Associated with Fatty Liver and Increased Visceral Fat Mass

Birgit Knebel; Jutta Haas; Sonja Hartwig; Sylvia Jacob; Cornelia Köllmer; Ulrike Nitzgen; Dirk Muller–Wieland; Jorg Kotzka

doi:10.1371/journal.pone.0031812

Loading metrics

Open Access

Peer-reviewed

Research Article

Liver-Specific Expression of Transcriptionally Active SREBP-1c Is Associated with Fatty Liver and Increased Visceral Fat Mass

Birgit Knebel,

Affiliation Institute of Clinical Biochemistry and Pathobiochemistry, German Diabetes Center at the Heinrich-Heine-University Duesseldorf, Leibniz Center for Diabetes Research, Duesseldorf, Germany
⨯
Jutta Haas,

Affiliation Institute for Diabetes Research, Department of General Internal Medicine, Asklepios Clinic St. Georg, Medical Faculty of the Semmelweis University, Hamburg, Germany
⨯
Sonja Hartwig,

Affiliation Institute of Clinical Biochemistry and Pathobiochemistry, German Diabetes Center at the Heinrich-Heine-University Duesseldorf, Leibniz Center for Diabetes Research, Duesseldorf, Germany
⨯
Sylvia Jacob,

Affiliation Institute of Clinical Biochemistry and Pathobiochemistry, German Diabetes Center at the Heinrich-Heine-University Duesseldorf, Leibniz Center for Diabetes Research, Duesseldorf, Germany
⨯
Cornelia Köllmer,

Affiliation Institute of Clinical Biochemistry and Pathobiochemistry, German Diabetes Center at the Heinrich-Heine-University Duesseldorf, Leibniz Center for Diabetes Research, Duesseldorf, Germany
⨯
Ulrike Nitzgen,

Affiliation Institute of Clinical Biochemistry and Pathobiochemistry, German Diabetes Center at the Heinrich-Heine-University Duesseldorf, Leibniz Center for Diabetes Research, Duesseldorf, Germany
⨯
Dirk Muller–Wieland,

Affiliation Institute for Diabetes Research, Department of General Internal Medicine, Asklepios Clinic St. Georg, Medical Faculty of the Semmelweis University, Hamburg, Germany
⨯
Jorg Kotzka

* E-mail: jkotzka@ddz.uni-duesseldorf.de

Affiliation Institute of Clinical Biochemistry and Pathobiochemistry, German Diabetes Center at the Heinrich-Heine-University Duesseldorf, Leibniz Center for Diabetes Research, Duesseldorf, Germany
⨯

Liver-Specific Expression of Transcriptionally Active SREBP-1c Is Associated with Fatty Liver and Increased Visceral Fat Mass

Birgit Knebel,
Jutta Haas,
Sonja Hartwig,
Sylvia Jacob,
Cornelia Köllmer,
Ulrike Nitzgen,
Dirk Muller–Wieland,
Jorg Kotzka

Published: February 21, 2012
https://doi.org/10.1371/journal.pone.0031812

Reader Comments (0)

Post a new comment on this article

Subject Areas
?

For more information about PLOS Subject Areas, click here.
We want your feedback. Do these Subject Areas make sense for this article? Click the target next to the incorrect Subject Area and let us know. Thanks for your help!

Mouse models
Is the Subject Area "Mouse models" applicable to this article?

Thanks for your feedback.
Lipids
Is the Subject Area "Lipids" applicable to this article?

Thanks for your feedback.
Fatty liver
Is the Subject Area "Fatty liver" applicable to this article?

Thanks for your feedback.
Fatty acids
Is the Subject Area "Fatty acids" applicable to this article?

Thanks for your feedback.
Adipose tissue
Is the Subject Area "Adipose tissue" applicable to this article?

Thanks for your feedback.
Genetically modified animals
Is the Subject Area "Genetically modified animals" applicable to this article?

Thanks for your feedback.
Cytokines
Is the Subject Area "Cytokines" applicable to this article?

Thanks for your feedback.
Gene expression
Is the Subject Area "Gene expression" applicable to this article?

Thanks for your feedback.