3, 3′-Diindolylmethane Exhibits Antileukemic Activity In Vitro and In Vivo through a Akt-Dependent Process

Ning Gao; Senping Cheng; Amit Budhraja; E-Hu Liu; Jieping Chen; Deying Chen; Zailin Yang; Jia Luo; Xianglin Shi; Zhuo Zhang

doi:10.1371/journal.pone.0031783

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Open Access

Peer-reviewed

Research Article

3, 3′-Diindolylmethane Exhibits Antileukemic Activity In Vitro and In Vivo through a Akt-Dependent Process

Ning Gao ,

* E-mail: gaoning59@yahoo.com.cn (NG); zhuo.zhang@uky.edu (ZZ)

Affiliations Department of Pharmacognosy, College of Pharmacy, 3rd Military Medical University, Chongqing, China, Graduate Center for Toxicology, College of Medicine, University of Kentucky, Lexington, Kentucky, United States of America
⨯
Senping Cheng,

Affiliation Graduate Center for Toxicology, College of Medicine, University of Kentucky, Lexington, Kentucky, United States of America
⨯
Amit Budhraja,

Affiliation Graduate Center for Toxicology, College of Medicine, University of Kentucky, Lexington, Kentucky, United States of America
⨯
E-Hu Liu,

Affiliation Department of Pharmacognosy, College of Pharmacy, 3rd Military Medical University, Chongqing, China
⨯
Jieping Chen,

Affiliation Department of Hematology, Southwest Hospital, 3rd Military Medical University, Chongqing, China
⨯
Deying Chen,

Affiliation Department of Pharmacognosy, College of Pharmacy, 3rd Military Medical University, Chongqing, China
⨯
Zailin Yang,

Affiliation Department of Hematology, Southwest Hospital, 3rd Military Medical University, Chongqing, China
⨯
Jia Luo,

Affiliation Department of Internal Medicine, University of Kentucky, Lexington, Kentucky, United States of America
⨯
Xianglin Shi,

Affiliation Graduate Center for Toxicology, College of Medicine, University of Kentucky, Lexington, Kentucky, United States of America
⨯
Zhuo Zhang

* E-mail: gaoning59@yahoo.com.cn (NG); zhuo.zhang@uky.edu (ZZ)

Affiliation Graduate Center for Toxicology, College of Medicine, University of Kentucky, Lexington, Kentucky, United States of America
⨯

3, 3′-Diindolylmethane Exhibits Antileukemic Activity In Vitro and In Vivo through a Akt-Dependent Process

Ning Gao,
Senping Cheng,
Amit Budhraja,
E-Hu Liu,
Jieping Chen,
Deying Chen,
Zailin Yang,
Jia Luo,
Xianglin Shi,
Zhuo Zhang

Published: February 21, 2012
https://doi.org/10.1371/journal.pone.0031783

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