Genome-Wide RNAi Screen in IFN-γ-Treated Human Macrophages Identifies Genes Mediating Resistance to the Intracellular Pathogen Francisella tularensis

Hongwei Zhou; Glen DeLoid; Erica Browning; David J. Gregory; Fengxiao Tan; Alice S. Bedugnis; Amy Imrich; Henry Koziel; Igor Kramnik; Quan Lu; Lester Kobzik

doi:10.1371/journal.pone.0031752

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Peer-reviewed

Research Article

Genome-Wide RNAi Screen in IFN-γ-Treated Human Macrophages Identifies Genes Mediating Resistance to the Intracellular Pathogen Francisella tularensis

Hongwei Zhou,

Current address: Department of Developmental and Regenerative Biology, Mount Sinai School of Medicine, New York, New York, United States of America

Affiliation Department of Environmental Health, Harvard School of Public Health, Boston, Massachusetts, United States of America
⨯
Glen DeLoid,

Affiliation Department of Environmental Health, Harvard School of Public Health, Boston, Massachusetts, United States of America
⨯
Erica Browning,

Affiliation Department of Environmental Health, Harvard School of Public Health, Boston, Massachusetts, United States of America
⨯
David J. Gregory,

Affiliation Department of Environmental Health, Harvard School of Public Health, Boston, Massachusetts, United States of America
⨯
Fengxiao Tan,

Affiliation Department of Environmental Health, Harvard School of Public Health, Boston, Massachusetts, United States of America
⨯
Alice S. Bedugnis,

Affiliation Department of Environmental Health, Harvard School of Public Health, Boston, Massachusetts, United States of America
⨯
Amy Imrich,

Affiliation Department of Environmental Health, Harvard School of Public Health, Boston, Massachusetts, United States of America
⨯
Henry Koziel,

Affiliation Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, United States of America
⨯
Igor Kramnik,

Affiliation Department of Medicine, Boston University School of Medicine, Boston, Massachusetts, United States of America
⨯
Quan Lu,

Affiliation Department of Environmental Health, Harvard School of Public Health, Boston, Massachusetts, United States of America
⨯
Lester Kobzik

* E-mail: lkobzik@hsph.harvard.edu

Affiliations Department of Environmental Health, Harvard School of Public Health, Boston, Massachusetts, United States of America, Department of Pathology, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, United States of America
⨯

Genome-Wide RNAi Screen in IFN-γ-Treated Human Macrophages Identifies Genes Mediating Resistance to the Intracellular Pathogen Francisella tularensis

Hongwei Zhou,
Glen DeLoid,
Erica Browning,
David J. Gregory,
Fengxiao Tan,
Alice S. Bedugnis,
Amy Imrich,
Henry Koziel,
Igor Kramnik,
Quan Lu

Published: February 16, 2012
https://doi.org/10.1371/journal.pone.0031752

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Francisella tularensis
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Macrophages
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Intracellular pathogens
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