The S4–S5 Linker Acts as a Signal Integrator for hERG K⁺ Channel Activation and Deactivation Gating

• Chai Ann Ng,

  Affiliations Molecular Cardiology and Biophysics Division, Victor Chang Cardiac Research Institute, Darlinghurst, New South Wales, Australia, School of Molecular Biosciences, University of Sydney, Sydney, New South Wales, Australia, St Vincent's Clinical School, University of New South Wales, New South Wales, Australia

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• Matthew D. Perry,

  Affiliation Molecular Cardiology and Biophysics Division, Victor Chang Cardiac Research Institute, Darlinghurst, New South Wales, Australia

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• Peter S. Tan,

  Affiliation Molecular Cardiology and Biophysics Division, Victor Chang Cardiac Research Institute, Darlinghurst, New South Wales, Australia

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• Adam P. Hill,

  Affiliations Molecular Cardiology and Biophysics Division, Victor Chang Cardiac Research Institute, Darlinghurst, New South Wales, Australia, St Vincent's Clinical School, University of New South Wales, New South Wales, Australia

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• Philip W. Kuchel,

  Affiliations School of Molecular Biosciences, University of Sydney, Sydney, New South Wales, Australia, Mechanistic Systems-biology NMR Group, Singapore Bioimaging Consortium, Agency for Science, Technology and Research, Singapore, Singapore

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• Jamie I. Vandenberg

  * E-mail: j.vandenberg@victorchang.edu.au

  Affiliations Molecular Cardiology and Biophysics Division, Victor Chang Cardiac Research Institute, Darlinghurst, New South Wales, Australia, School of Molecular Biosciences, University of Sydney, Sydney, New South Wales, Australia, St Vincent's Clinical School, University of New South Wales, New South Wales, Australia

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