Genome Wide Adaptations of Plasmodium falciparum in Response to Lumefantrine Selective Drug Pressure

Leah Mwai; Abdi Diriye; Victor Masseno; Steven Muriithi; Theresa Feltwell; Jennifer Musyoki; Jacob Lemieux; Avi Feller; Gunnar R. Mair; Kevin Marsh; Chris Newbold; Alexis Nzila; Céline K. Carret

doi:10.1371/journal.pone.0031623

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Open Access

Peer-reviewed

Research Article

Genome Wide Adaptations of Plasmodium falciparum in Response to Lumefantrine Selective Drug Pressure

Leah Mwai,

Affiliations Kenya Medical Research Institute, Welcome Trust Research Programme, Kilifi, Kenya, Nuffield Department of Medicine, John Radcliffe Hospital, University of Oxford, Oxford, United Kingdom
⨯
Abdi Diriye,

Affiliation Kenya Medical Research Institute, Welcome Trust Research Programme, Kilifi, Kenya
⨯
Victor Masseno,

Affiliation Kenya Medical Research Institute, Welcome Trust Research Programme, Kilifi, Kenya
⨯
Steven Muriithi,

Affiliation Kenya Medical Research Institute, Welcome Trust Research Programme, Kilifi, Kenya
⨯
Theresa Feltwell,

Affiliation Pathogen Microarrays group, The Welcome Trust Sanger Institute, Cambridge, United Kingdom
⨯
Jennifer Musyoki,

Affiliation Kenya Medical Research Institute, Welcome Trust Research Programme, Kilifi, Kenya
⨯
Jacob Lemieux,

Affiliation Weatherall Institute of Molecular Medicine, John Radcliffe Hospital, University of Oxford, Oxford, United Kingdom
⨯
Avi Feller,

Affiliation Department of Statistics, University of Oxford, Oxford, United Kingdom
⨯
Gunnar R. Mair,

Affiliation Molecular Parasitology Unit, Instituto de Medicina Molecular, Lisboa, Portugal
⨯
Kevin Marsh,

Affiliations Kenya Medical Research Institute, Welcome Trust Research Programme, Kilifi, Kenya, Nuffield Department of Medicine, John Radcliffe Hospital, University of Oxford, Oxford, United Kingdom
⨯
Chris Newbold,

Affiliation Weatherall Institute of Molecular Medicine, John Radcliffe Hospital, University of Oxford, Oxford, United Kingdom
⨯
Alexis Nzila,

Affiliations Kenya Medical Research Institute, Welcome Trust Research Programme, Kilifi, Kenya, Nuffield Department of Medicine, John Radcliffe Hospital, University of Oxford, Oxford, United Kingdom
⨯
Céline K. Carret

* E-mail: ccarret@fm.ul.pt

Affiliation Molecular Parasitology Unit, Instituto de Medicina Molecular, Lisboa, Portugal
⨯

Genome Wide Adaptations of Plasmodium falciparum in Response to Lumefantrine Selective Drug Pressure

Leah Mwai,
Abdi Diriye,
Victor Masseno,
Steven Muriithi,
Theresa Feltwell,
Jennifer Musyoki,
Jacob Lemieux,
Avi Feller,
Gunnar R. Mair,
Kevin Marsh

Published: February 27, 2012
https://doi.org/10.1371/journal.pone.0031623

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