Endothelium Derived Nitric Oxide Synthase Negatively Regulates the PDGF-Survivin Pathway during Flow-Dependent Vascular Remodeling

Jun Yu; Yuanyuan Zhang; Xinbo Zhang; R. Daniel Rudic; Philip M. Bauer; Dario C. Altieri; William C. Sessa

doi:10.1371/journal.pone.0031495

Loading metrics

Open Access

Peer-reviewed

Research Article

Endothelium Derived Nitric Oxide Synthase Negatively Regulates the PDGF-Survivin Pathway during Flow-Dependent Vascular Remodeling

Jun Yu ,

* E-mail: jun.yu@yale.edu

Affiliations Vascular Biology and Therapeutics Program, Yale University School of Medicine, New Haven, Connecticut, United States of America, Internal Medicine Section of Cardiovascular Medicine, Yale University School of Medicine, New Haven, Connecticut, United States of America
⨯
Yuanyuan Zhang,

Affiliations Vascular Biology and Therapeutics Program, Yale University School of Medicine, New Haven, Connecticut, United States of America, Internal Medicine Section of Cardiovascular Medicine, Yale University School of Medicine, New Haven, Connecticut, United States of America
⨯
Xinbo Zhang,

Affiliations Vascular Biology and Therapeutics Program, Yale University School of Medicine, New Haven, Connecticut, United States of America, Internal Medicine Section of Cardiovascular Medicine, Yale University School of Medicine, New Haven, Connecticut, United States of America
⨯
R. Daniel Rudic,

Current address: Department of Pharmacology and Toxicology, Georgia Health Sciences University, Augusta, Georgia, United States of America

Affiliation Vascular Biology and Therapeutics Program, Yale University School of Medicine, New Haven, Connecticut, United States of America
⨯
Philip M. Bauer,

Current address: Department of Surgery, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America

Affiliation Vascular Biology and Therapeutics Program, Yale University School of Medicine, New Haven, Connecticut, United States of America
⨯
Dario C. Altieri,

Affiliation The Wistar Institute Cancer Center, Philadelphia, Pennsylvania, United States of America
⨯
William C. Sessa

Affiliation Vascular Biology and Therapeutics Program, Yale University School of Medicine, New Haven, Connecticut, United States of America
⨯

Endothelium Derived Nitric Oxide Synthase Negatively Regulates the PDGF-Survivin Pathway during Flow-Dependent Vascular Remodeling

Jun Yu,
Yuanyuan Zhang,
Xinbo Zhang,
R. Daniel Rudic,
Philip M. Bauer,
Dario C. Altieri,
William C. Sessa

Published: February 15, 2012
https://doi.org/10.1371/journal.pone.0031495

Reader Comments (0)

Post a new comment on this article

Subject Areas
?

For more information about PLOS Subject Areas, click here.
We want your feedback. Do these Subject Areas make sense for this article? Click the target next to the incorrect Subject Area and let us know. Thanks for your help!

Apoptosis
Is the Subject Area "Apoptosis" applicable to this article?

Thanks for your feedback.
Nitric oxide
Is the Subject Area "Nitric oxide" applicable to this article?

Thanks for your feedback.
Carotid arteries
Is the Subject Area "Carotid arteries" applicable to this article?

Thanks for your feedback.
Genetically modified animals
Is the Subject Area "Genetically modified animals" applicable to this article?

Thanks for your feedback.
Blood flow
Is the Subject Area "Blood flow" applicable to this article?

Thanks for your feedback.
Cell proliferation
Is the Subject Area "Cell proliferation" applicable to this article?

Thanks for your feedback.
Endothelium
Is the Subject Area "Endothelium" applicable to this article?

Thanks for your feedback.
Growth factors
Is the Subject Area "Growth factors" applicable to this article?

Thanks for your feedback.