Inhibition of Transforming Growth Factor-Activated Kinase 1 (TAK1) Blocks and Reverses Epithelial to Mesenchymal Transition of Mesothelial Cells

Raffaele Strippoli; Ignacio Benedicto; Maria Luisa Perez Lozano; Teijo Pellinen; Pilar Sandoval; Manuel Lopez-Cabrera; Miguel Angel del Pozo

doi:10.1371/journal.pone.0031492

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Peer-reviewed

Research Article

Inhibition of Transforming Growth Factor-Activated Kinase 1 (TAK1) Blocks and Reverses Epithelial to Mesenchymal Transition of Mesothelial Cells

Raffaele Strippoli,

Affiliations Integrin Signaling Laboratory, Department of Vascular Biology and Inflammation, Centro Nacional de Investigaciones Cardiovasculares (CNIC), Madrid, Spain, Bambino Gesù Children's Hospital, Rome, Italy
⨯
Ignacio Benedicto,

Affiliations Unidad de Biología Molecular, Instituto de Investigación Sanitaria Princesa (IP), Hospital Universitario de la Princesa, Madrid, Spain, CIBER-ehd, Instituto de Salud Carlos III, Madrid, Spain
⨯
Maria Luisa Perez Lozano,

Affiliations Unidad de Biología Molecular, Instituto de Investigación Sanitaria Princesa (IP), Hospital Universitario de la Princesa, Madrid, Spain, Centro de Biología Molecular Severo Ochoa, CSIC-UAM, Cantoblanco, Madrid, Spain
⨯
Teijo Pellinen,

Affiliation Integrin Signaling Laboratory, Department of Vascular Biology and Inflammation, Centro Nacional de Investigaciones Cardiovasculares (CNIC), Madrid, Spain
⨯
Pilar Sandoval,

Affiliations Unidad de Biología Molecular, Instituto de Investigación Sanitaria Princesa (IP), Hospital Universitario de la Princesa, Madrid, Spain, Centro de Biología Molecular Severo Ochoa, CSIC-UAM, Cantoblanco, Madrid, Spain
⨯
Manuel Lopez-Cabrera ,

Contributed equally to this work with: Manuel Lopez-Cabrera, Miguel Angel del Pozo

Affiliations Unidad de Biología Molecular, Instituto de Investigación Sanitaria Princesa (IP), Hospital Universitario de la Princesa, Madrid, Spain, CIBER-ehd, Instituto de Salud Carlos III, Madrid, Spain, Centro de Biología Molecular Severo Ochoa, CSIC-UAM, Cantoblanco, Madrid, Spain
⨯
Miguel Angel del Pozo

Contributed equally to this work with: Manuel Lopez-Cabrera, Miguel Angel del Pozo

* E-mail: madelpozo@cnic.es

Affiliation Integrin Signaling Laboratory, Department of Vascular Biology and Inflammation, Centro Nacional de Investigaciones Cardiovasculares (CNIC), Madrid, Spain
⨯

Inhibition of Transforming Growth Factor-Activated Kinase 1 (TAK1) Blocks and Reverses Epithelial to Mesenchymal Transition of Mesothelial Cells

Raffaele Strippoli,
Ignacio Benedicto,
Maria Luisa Perez Lozano,
Teijo Pellinen,
Pilar Sandoval,
Manuel Lopez-Cabrera,
Miguel Angel del Pozo

Published: February 27, 2012
https://doi.org/10.1371/journal.pone.0031492

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