Small RNAs Targeting Transcription Start Site Induce Heparanase Silencing through Interference with Transcription Initiation in Human Cancer Cells

Guosong Jiang; Liduan Zheng; Jiarui Pu; Hong Mei; Jun Zhao; Kai Huang; Fuqing Zeng; Qiangsong Tong

doi:10.1371/journal.pone.0031379

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Open Access

Peer-reviewed

Research Article

Small RNAs Targeting Transcription Start Site Induce Heparanase Silencing through Interference with Transcription Initiation in Human Cancer Cells

Guosong Jiang ,

Contributed equally to this work with: Guosong Jiang, Liduan Zheng

Affiliation Department of Surgery, Union Hospital of Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei Province, China
⨯
Liduan Zheng ,

Contributed equally to this work with: Guosong Jiang, Liduan Zheng

Affiliations Department of Pathology, Union Hospital of Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei Province, China, Human Disease Related Gene Research Group, Union Hospital of Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei Province, China
⨯
Jiarui Pu,

Affiliation Department of Surgery, Union Hospital of Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei Province, China
⨯
Hong Mei,

Affiliation Department of Surgery, Union Hospital of Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei Province, China
⨯
Jun Zhao,

Affiliation Department of Surgery, Union Hospital of Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei Province, China
⨯
Kai Huang,

Affiliations Human Disease Related Gene Research Group, Union Hospital of Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei Province, China, Department of Cardiology, Union Hospital of Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei Province, China
⨯
Fuqing Zeng ,

* E-mail: zengfuqingunion@hotmail.com (FQZ) (FZ); qs_tong@hotmail.com (QST) (QT)

Affiliation Department of Surgery, Union Hospital of Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei Province, China
⨯
Qiangsong Tong

* E-mail: zengfuqingunion@hotmail.com (FQZ) (FZ); qs_tong@hotmail.com (QST) (QT)

Affiliations Department of Surgery, Union Hospital of Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei Province, China, Human Disease Related Gene Research Group, Union Hospital of Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei Province, China
⨯

Small RNAs Targeting Transcription Start Site Induce Heparanase Silencing through Interference with Transcription Initiation in Human Cancer Cells

Guosong Jiang,
Liduan Zheng,
Jiarui Pu,
Hong Mei,
Jun Zhao,
Kai Huang,
Fuqing Zeng,
Qiangsong Tong

Published: February 20, 2012
https://doi.org/10.1371/journal.pone.0031379

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Small interfering RNA
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Transfection
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Cancers and neoplasms
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DNA methylation
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Gastric cancer
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