Impact of the Herbal Medicine Sophora flavescens on the Oral Pharmacokinetics of Indinavir in Rats: The Involvement of CYP3A and P-Glycoprotein

• Jia-Ming Yang,

  Affiliation School of Chinese Medicine, The Chinese University of Hong Kong, Shatin, Hong Kong

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• Siu-Po Ip,

  Affiliation School of Chinese Medicine, The Chinese University of Hong Kong, Shatin, Hong Kong

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• Yanfang Xian,

  Affiliation School of Chinese Medicine, The Chinese University of Hong Kong, Shatin, Hong Kong

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• Ming Zhao,

  Affiliations School of Chinese Medicine, The Chinese University of Hong Kong, Shatin, Hong Kong, Department of Medicinal Chemistry and Pharmacognosy, University of Illinois at Chicago, Chicago, Illinois, United States of America

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• Zhi-Xiu Lin,

  Affiliation School of Chinese Medicine, The Chinese University of Hong Kong, Shatin, Hong Kong

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• John Hok Keung Yeung,

  Affiliation School of Biomedical Science, The Chinese University of Hong Kong, Shatin, Hong Kong

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• Raphael Chiu Yeung Chan,

  Affiliation Department of Microbiology, The Chinese University of Hong Kong, Shatin, Hong Kong

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• Shui-Shan Lee,

  Affiliations Department of Microbiology, The Chinese University of Hong Kong, Shatin, Hong Kong, Stanley Ho Centre for Emerging Infectious Diseases, The Chinese University of Hong Kong, Shatin, Hong Kong

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• Chun-Tao Che

  * E-mail: chect@uic.edu

  Affiliations School of Chinese Medicine, The Chinese University of Hong Kong, Shatin, Hong Kong, Department of Medicinal Chemistry and Pharmacognosy, University of Illinois at Chicago, Chicago, Illinois, United States of America

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