Persistence versus Escape: Aspergillus terreus and Aspergillus fumigatus Employ Different Strategies during Interactions with Macrophages

Silvia Slesiona; Markus Gressler; Michael Mihlan; Christoph Zaehle; Martin Schaller; Dagmar Barz; Bernhard Hube; Ilse D. Jacobsen; Matthias Brock

doi:10.1371/journal.pone.0031223

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Peer-reviewed

Research Article

Persistence versus Escape: Aspergillus terreus and Aspergillus fumigatus Employ Different Strategies during Interactions with Macrophages

Silvia Slesiona,

Affiliations Microbial Biochemistry and Physiology, Leibniz Institute for Natural Product Research and Infection Biology, Hans Knoell Institute, Jena, Germany, Microbial Pathogenicity Mechanisms, Leibniz Institute for Natural Product Research and Infection Biology, Hans Knoell Institute, Jena, Germany
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Markus Gressler,

Affiliation Microbial Biochemistry and Physiology, Leibniz Institute for Natural Product Research and Infection Biology, Hans Knoell Institute, Jena, Germany
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Michael Mihlan,

Affiliation Infection Biology, Leibniz Institute for Natural Product Research and Infection Biology, Hans Knoell Institute, Jena, Germany
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Christoph Zaehle,

Affiliation Biomolecular Chemistry, Leibniz Institute for Natural Product Research and Infection Biology, Hans Knoell Institute, Jena, Germany
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Martin Schaller,

Affiliation Department of Dermatology, Eberhard-Karls-University, Tübingen, Germany
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Dagmar Barz,

Affiliation Institute for Transfusion Medicine, University Hospital, Jena, Germany
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Bernhard Hube,

Affiliations Microbial Pathogenicity Mechanisms, Leibniz Institute for Natural Product Research and Infection Biology, Hans Knoell Institute, Jena, Germany, Friedrich Schiller University, Jena, Germany
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Ilse D. Jacobsen ,

* E-mail: Ilse.jacobsen@hki-jena.de (IDJ); Matthias.brock@hki-jena.de (MB)

Affiliation Microbial Pathogenicity Mechanisms, Leibniz Institute for Natural Product Research and Infection Biology, Hans Knoell Institute, Jena, Germany
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Matthias Brock

* E-mail: Ilse.jacobsen@hki-jena.de (IDJ); Matthias.brock@hki-jena.de (MB)

Affiliation Microbial Biochemistry and Physiology, Leibniz Institute for Natural Product Research and Infection Biology, Hans Knoell Institute, Jena, Germany
⨯

Persistence versus Escape: Aspergillus terreus and Aspergillus fumigatus Employ Different Strategies during Interactions with Macrophages

Silvia Slesiona,
Markus Gressler,
Michael Mihlan,
Christoph Zaehle,
Martin Schaller,
Dagmar Barz,
Bernhard Hube,
Ilse D. Jacobsen,
Matthias Brock

Published: February 3, 2012
https://doi.org/10.1371/journal.pone.0031223

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Aspergillus fumigatus
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Macrophages
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Phagocytosis
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Alveolar macrophages
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Aspergillus nidulans
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Toll-like receptors
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Cytotoxicity
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Mannose
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