Dehydrocostuslactone Suppresses Angiogenesis In Vitro and In Vivo through Inhibition of Akt/GSK-3β and mTOR Signaling Pathways

• Chih-Ya Wang,

  Affiliation Pharmacological Institute, College of Medicine, National Taiwan University, Taipei, Taiwan

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• An-Chi Tsai,

  Affiliation Institute of Biotechnology and Pharmaceutical Research, National Health Research Institutes, Zhunan Town, Taiwan

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• Chieh-Yu Peng,

  Affiliations Natural Medicinal Products Research Center, China Medical University Hospital, Taichung, Taiwan, Graduate Institute of Integrated Medicine, College of Chinese Medicine, China Medical University, Taichung, Taiwan

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• Ya-Ling Chang,

  Affiliation Pharmacological Institute, College of Medicine, National Taiwan University, Taipei, Taiwan

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• Kuo-Hsiung Lee,

  Affiliations Natural Products Research Laboratories, Eshelman School of Pharmacy, University of North Carolina, Chapel Hill, North Carolina, United States of America, Chinese Medicine Research and Development Center, China Medical University and Hospital, Taichung, Taiwan

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• Che-Ming Teng ,

  Contributed equally to this work with: Che-Ming Teng, Shiow-Lin Pan

  * E-mail: apan0826@nhri.org.tw (SP); cmteng@ntu.edu.tw(CT)

  Affiliation Pharmacological Institute, College of Medicine, National Taiwan University, Taipei, Taiwan

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• Shiow-Lin Pan

  Contributed equally to this work with: Che-Ming Teng, Shiow-Lin Pan

  * E-mail: apan0826@nhri.org.tw (SP); cmteng@ntu.edu.tw(CT)

  Affiliation Institute of Biotechnology and Pharmaceutical Research, National Health Research Institutes, Zhunan Town, Taiwan

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