A Francisella tularensis Live Vaccine Strain That Improves Stimulation of Antigen-Presenting Cells Does Not Enhance Vaccine Efficacy

Deanna M. Schmitt; Dawn M. O'Dee; Joseph Horzempa; Paul E. Carlson Jr; Brian C. Russo; Jacqueline M. Bales; Matthew J. Brown; Gerard J. Nau

doi:10.1371/journal.pone.0031172

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Peer-reviewed

Research Article

A Francisella tularensis Live Vaccine Strain That Improves Stimulation of Antigen-Presenting Cells Does Not Enhance Vaccine Efficacy

Deanna M. Schmitt,

Affiliation Department of Microbiology and Molecular Genetics, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, United States of America
⨯
Dawn M. O'Dee,

Affiliation Department of Microbiology and Molecular Genetics, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, United States of America
⨯
Joseph Horzempa,

Affiliations Department of Microbiology and Molecular Genetics, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, United States of America, Department of Natural Sciences and Mathematics, West Liberty University, West Liberty, West Virginia, United States of America
⨯
Paul E. Carlson Jr,

Current address: Department of Microbiology and Immunology, University of Michigan Medical School, Ann Arbor, Michigan, United States of America

Affiliation Department of Microbiology and Molecular Genetics, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, United States of America
⨯
Brian C. Russo,

Affiliation Department of Microbiology and Molecular Genetics, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, United States of America
⨯
Jacqueline M. Bales,

Affiliation Department of Microbiology and Molecular Genetics, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, United States of America
⨯
Matthew J. Brown,

Affiliation Department of Microbiology and Molecular Genetics, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, United States of America
⨯
Gerard J. Nau

* E-mail: gjnau@pitt.edu

Affiliations Department of Microbiology and Molecular Genetics, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, United States of America, Department of Medicine – Division of Infectious Diseases, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, United States of America, Center for Vaccine Research, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, United States of America
⨯

A Francisella tularensis Live Vaccine Strain That Improves Stimulation of Antigen-Presenting Cells Does Not Enhance Vaccine Efficacy

Deanna M. Schmitt,
Dawn M. O'Dee,
Joseph Horzempa,
Paul E. Carlson Jr,
Brian C. Russo,
Jacqueline M. Bales,
Matthew J. Brown,
Gerard J. Nau

Published: February 15, 2012
https://doi.org/10.1371/journal.pone.0031172

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T cells
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Francisella tularensis
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Francisella
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