Brain Deletion of Insulin Receptor Substrate 2 Disrupts Hippocampal Synaptic Plasticity and Metaplasticity

Derek A. Costello; Marc Claret; Hind Al-Qassab; Florian Plattner; Elaine E. Irvine; Agharul I. Choudhury; K. Peter Giese; Dominic J. Withers; Paola Pedarzani

doi:10.1371/journal.pone.0031124

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Peer-reviewed

Research Article

Brain Deletion of Insulin Receptor Substrate 2 Disrupts Hippocampal Synaptic Plasticity and Metaplasticity

Derek A. Costello,

Current address: Department of Physiology, Institute of Neuroscience, Trinity College, Dublin, Ireland

Affiliation Research Department of Neuroscience, Physiology and Pharmacology, University College London, London, United Kingdom
⨯
Marc Claret,

Current address: Diabetes and Obesity Laboratory, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Centro de Investigación Biomédica en Red de Diabetes y Enfermedades Metabólicas Asociadas (CIBERDEM), Barcelona, Spain

Affiliation Department of Medicine, University College London, London, United Kingdom
⨯
Hind Al-Qassab,

Affiliation Department of Medicine, University College London, London, United Kingdom
⨯
Florian Plattner,

Affiliation Wolfson Institute of Biomedical Research, University College London, London, United Kingdom
⨯
Elaine E. Irvine,

Affiliations Department of Medicine, University College London, London, United Kingdom, Wolfson Institute of Biomedical Research, University College London, London, United Kingdom, Metabolic Signalling Group, MRC Clinical Sciences Centre, Imperial College London, London, United Kingdom
⨯
Agharul I. Choudhury,

Affiliations Department of Medicine, University College London, London, United Kingdom, Metabolic Signalling Group, MRC Clinical Sciences Centre, Imperial College London, London, United Kingdom
⨯
K. Peter Giese,

Current address: Centre for the Cellular Basis of Behaviour, MRC Centre for Neurodegeneration Research, Institute of Psychiatry, King's College London, London, United Kingdom

Affiliation Wolfson Institute of Biomedical Research, University College London, London, United Kingdom
⨯
Dominic J. Withers,

Affiliations Department of Medicine, University College London, London, United Kingdom, Metabolic Signalling Group, MRC Clinical Sciences Centre, Imperial College London, London, United Kingdom
⨯
Paola Pedarzani

* E-mail: p.pedarzani@ucl.ac.uk

Affiliation Research Department of Neuroscience, Physiology and Pharmacology, University College London, London, United Kingdom
⨯

Brain Deletion of Insulin Receptor Substrate 2 Disrupts Hippocampal Synaptic Plasticity and Metaplasticity

Derek A. Costello,
Marc Claret,
Hind Al-Qassab,
Florian Plattner,
Elaine E. Irvine,
Agharul I. Choudhury,
K. Peter Giese,
Dominic J. Withers,
Paola Pedarzani

Published: February 27, 2012
https://doi.org/10.1371/journal.pone.0031124

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Excitatory postsynaptic potentials
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Hippocampus
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Mouse models
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Synaptic plasticity
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