Disease-Toxicant Interactions in Manganese Exposed Huntington Disease Mice: Early Changes in Striatal Neuron Morphology and Dopamine Metabolism

Jennifer L. Madison; Michal Wegrzynowicz; Michael Aschner; Aaron B. Bowman

doi:10.1371/journal.pone.0031024

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Peer-reviewed

Research Article

Disease-Toxicant Interactions in Manganese Exposed Huntington Disease Mice: Early Changes in Striatal Neuron Morphology and Dopamine Metabolism

Jennifer L. Madison,

Affiliations Department of Pharmacology, Vanderbilt University Medical Center, Nashville, Tennessee, United States of America, Department of Neurology, Vanderbilt University Medical Center, Nashville, Tennessee, United States of America
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Michal Wegrzynowicz,

Affiliation Department of Neurology, Vanderbilt University Medical Center, Nashville, Tennessee, United States of America
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Michael Aschner,

Affiliations Department of Pharmacology, Vanderbilt University Medical Center, Nashville, Tennessee, United States of America, Department of Pediatrics, Vanderbilt University Medical Center, Nashville, Tennessee, United States of America, Vanderbilt University Kennedy Center for Research on Human Development, Vanderbilt University Medical Center, Nashville, Tennessee, United States of America, Center for Molecular Neuroscience, Vanderbilt University Medical Center, Nashville, Tennessee, United States of America, Center in Molecular Toxicology, Vanderbilt University Medical Center, Nashville, Tennessee, United States of America
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Aaron B. Bowman

* E-mail: aaron.bowman@vanderbilt.edu

Affiliations Department of Neurology, Vanderbilt University Medical Center, Nashville, Tennessee, United States of America, Department of Pediatrics, Vanderbilt University Medical Center, Nashville, Tennessee, United States of America, Vanderbilt University Kennedy Center for Research on Human Development, Vanderbilt University Medical Center, Nashville, Tennessee, United States of America, Center for Molecular Neuroscience, Vanderbilt University Medical Center, Nashville, Tennessee, United States of America, Center in Molecular Toxicology, Vanderbilt University Medical Center, Nashville, Tennessee, United States of America
⨯

Disease-Toxicant Interactions in Manganese Exposed Huntington Disease Mice: Early Changes in Striatal Neuron Morphology and Dopamine Metabolism

Jennifer L. Madison,
Michal Wegrzynowicz,
Michael Aschner,
Aaron B. Bowman

Published: February 17, 2012
https://doi.org/10.1371/journal.pone.0031024

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Neuronal dendrites
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Manganese
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Mouse models
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Neostriatum
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Neuronal morphology
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Huntington disease
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