A miR-1207-5p Binding Site Polymorphism Abolishes Regulation of HBEGF and Is Associated with Disease Severity in CFHR5 Nephropathy

Gregory Papagregoriou; Kamil Erguler; Harsh Dweep; Konstantinos Voskarides; Panayiota Koupepidou; Yiannis Athanasiou; Alkis Pierides; Norbert Gretz; Kyriacos N. Felekkis; Constantinos Deltas

doi:10.1371/journal.pone.0031021

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Peer-reviewed

Research Article

A miR-1207-5p Binding Site Polymorphism Abolishes Regulation of HBEGF and Is Associated with Disease Severity in CFHR5 Nephropathy

Gregory Papagregoriou,

Affiliation Molecular Medicine Research Center and Laboratory of Molecular and Medical Genetics, Department of Biological Sciences, University of Cyprus, Nicosia, Cyprus
⨯
Kamil Erguler,

Affiliation Molecular Medicine Research Center and Laboratory of Molecular and Medical Genetics, Department of Biological Sciences, University of Cyprus, Nicosia, Cyprus
⨯
Harsh Dweep,

Affiliation Medical Research Center, University of Heidelberg, Mannheim, Germany
⨯
Konstantinos Voskarides,

Affiliation Molecular Medicine Research Center and Laboratory of Molecular and Medical Genetics, Department of Biological Sciences, University of Cyprus, Nicosia, Cyprus
⨯
Panayiota Koupepidou,

Affiliation Molecular Medicine Research Center and Laboratory of Molecular and Medical Genetics, Department of Biological Sciences, University of Cyprus, Nicosia, Cyprus
⨯
Yiannis Athanasiou,

Affiliation Department of Nephrology, Nicosia General Hospital, Nicosia, Cyprus
⨯
Alkis Pierides,

Affiliation Department of Nephrology, Hippocrateon Hospital, Nicosia, Cyprus
⨯
Norbert Gretz,

Affiliation Medical Research Center, University of Heidelberg, Mannheim, Germany
⨯
Kyriacos N. Felekkis ,

Contributed equally to this work with: Kyriacos N. Felekkis, Constantinos Deltas

* E-mail: felekkis.k@unic.ac.cy (KNF); Deltas@ucy.ac.cy (CD)

Affiliation Department of Life and Health Sciences, University of Nicosia, Nicosia, Cyprus
⨯
Constantinos Deltas

Contributed equally to this work with: Kyriacos N. Felekkis, Constantinos Deltas

* E-mail: felekkis.k@unic.ac.cy (KNF); Deltas@ucy.ac.cy (CD)

Affiliation Molecular Medicine Research Center and Laboratory of Molecular and Medical Genetics, Department of Biological Sciences, University of Cyprus, Nicosia, Cyprus
⨯

A miR-1207-5p Binding Site Polymorphism Abolishes Regulation of HBEGF and Is Associated with Disease Severity in CFHR5 Nephropathy

Gregory Papagregoriou,
Kamil Erguler,
Harsh Dweep,
Konstantinos Voskarides,
Panayiota Koupepidou,
Yiannis Athanasiou,
Alkis Pierides,
Norbert Gretz,
Kyriacos N. Felekkis,
Constantinos Deltas

Published: February 2, 2012
https://doi.org/10.1371/journal.pone.0031021

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