Structure-Based Rational Design of a Toll-like Receptor 4 (TLR4) Decoy Receptor with High Binding Affinity for a Target Protein

Jieun Han; Hyun Jung Kim; Sang-Chul Lee; Seungpyo Hong; Keunwan Park; Young Ho Jeon; Dongsup Kim; Hae-Kap Cheong; Hak-Sung Kim

doi:10.1371/journal.pone.0030929

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Open Access

Peer-reviewed

Research Article

Structure-Based Rational Design of a Toll-like Receptor 4 (TLR4) Decoy Receptor with High Binding Affinity for a Target Protein

Jieun Han ,

Contributed equally to this work with: Jieun Han, Hyun Jung Kim

Affiliation Department of Biological Sciences, Korea Advanced Institute of Science and Technology (KAIST), Yuseong-gu, Daejeon, Korea
⨯
Hyun Jung Kim ,

Contributed equally to this work with: Jieun Han, Hyun Jung Kim

Affiliations Division of Magnetic Resonance Research, Korea Basic Science Institute, Cheongwon, Chungbuk, Korea, College of Pharmacy, Chungbuk National University, Cheongju, Chungbuk, Korea
⨯
Sang-Chul Lee,

Current address: Institute Pasteur Korea, Bundang-gu, Seongnam-si, Gyeonggi-do, Korea

Affiliation Department of Biological Sciences, Korea Advanced Institute of Science and Technology (KAIST), Yuseong-gu, Daejeon, Korea
⨯
Seungpyo Hong,

Affiliation Department of Bio and Brain Engineering, Korea Advanced Institute of Science and Technology (KAIST), Yuseong-gu, Daejeon, Korea
⨯
Keunwan Park,

Affiliation Department of Bio and Brain Engineering, Korea Advanced Institute of Science and Technology (KAIST), Yuseong-gu, Daejeon, Korea
⨯
Young Ho Jeon,

Affiliation Division of Magnetic Resonance Research, Korea Basic Science Institute, Cheongwon, Chungbuk, Korea
⨯
Dongsup Kim,

Affiliation Department of Bio and Brain Engineering, Korea Advanced Institute of Science and Technology (KAIST), Yuseong-gu, Daejeon, Korea
⨯
Hae-Kap Cheong ,

* E-mail: haekap@kbsi.re.kr (H-KC); hskim76@kaist.ac.kr (H-SK)

Affiliation Division of Magnetic Resonance Research, Korea Basic Science Institute, Cheongwon, Chungbuk, Korea
⨯
Hak-Sung Kim

* E-mail: haekap@kbsi.re.kr (H-KC); hskim76@kaist.ac.kr (H-SK)

Affiliations Department of Biological Sciences, Korea Advanced Institute of Science and Technology (KAIST), Yuseong-gu, Daejeon, Korea, Graduate School of Nanoscience and Technology, Korea Advanced Institute of Science and Technology (KAIST), Yuseong-gu, Daejeon, Korea
⨯

Structure-Based Rational Design of a Toll-like Receptor 4 (TLR4) Decoy Receptor with High Binding Affinity for a Target Protein

Jieun Han,
Hyun Jung Kim,
Sang-Chul Lee,
Seungpyo Hong,
Keunwan Park,
Young Ho Jeon,
Dongsup Kim,
Hae-Kap Cheong,
Hak-Sung Kim

Published: February 17, 2012
https://doi.org/10.1371/journal.pone.0030929

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Crystal structure
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Toll-like receptors
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Hydrogen bonding
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Molecular dynamics
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Substitution mutation
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Protein interactions
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Binding analysis
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Extracellular matrix proteins
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