Noradrenergic α1 Receptor Antagonist Treatment Attenuates Positive Subjective Effects of Cocaine in Humans: A Randomized Trial

Open Access

Peer-reviewed

Research Article

Noradrenergic α₁ Receptor Antagonist Treatment Attenuates Positive Subjective Effects of Cocaine in Humans: A Randomized Trial

Thomas F. Newton ,

* E-mail: tnewton@bcm.edu

Affiliation Menninger Department of Psychiatry & Behavioral Sciences, Baylor College of Medicine, Michael E. DeBakey Veterans Affairs Medical Center, Houston, Texas, United States of America
⨯
Richard De La Garza II,

Affiliation Menninger Department of Psychiatry & Behavioral Sciences, Baylor College of Medicine, Michael E. DeBakey Veterans Affairs Medical Center, Houston, Texas, United States of America
⨯
Gregory Brown,

Affiliation Menninger Department of Psychiatry & Behavioral Sciences, Baylor College of Medicine, Michael E. DeBakey Veterans Affairs Medical Center, Houston, Texas, United States of America
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Thomas R. Kosten,

Affiliation Menninger Department of Psychiatry & Behavioral Sciences, Baylor College of Medicine, Michael E. DeBakey Veterans Affairs Medical Center, Houston, Texas, United States of America
⨯
James J. Mahoney III,

Affiliation Menninger Department of Psychiatry & Behavioral Sciences, Baylor College of Medicine, Michael E. DeBakey Veterans Affairs Medical Center, Houston, Texas, United States of America
⨯
Colin N. Haile

Affiliation Menninger Department of Psychiatry & Behavioral Sciences, Baylor College of Medicine, Michael E. DeBakey Veterans Affairs Medical Center, Houston, Texas, United States of America
⨯

Cocaine
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Blood pressure
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Heart rate
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Receptor antagonist therapy
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Drug therapy
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Cardiovascular therapy
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Nicotine replacement therapy
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Drug dependence
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