MicroRNA 146a (miR-146a) Is Over-Expressed during Prion Disease and Modulates the Innate Immune Response and the Microglial Activation State

Reuben Saba; Shantel Gushue; Rhiannon L. C. H. Huzarewich; Kathy Manguiat; Sarah Medina; Catherine Robertson; Stephanie A. Booth

doi:10.1371/journal.pone.0030832

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Open Access

Peer-reviewed

Research Article

MicroRNA 146a (miR-146a) Is Over-Expressed during Prion Disease and Modulates the Innate Immune Response and the Microglial Activation State

Reuben Saba ,

Contributed equally to this work with: Reuben Saba, Shantel Gushue

Affiliations Molecular PathoBiology, National Microbiology Laboratory, Public Health Agency of Canada, Winnipeg, Manitoba, Canada, Department of Medical Microbiology and Infectious Diseases, University of Manitoba, Winnipeg, Manitoba, Canada
⨯
Shantel Gushue ,

Contributed equally to this work with: Reuben Saba, Shantel Gushue

Affiliations Molecular PathoBiology, National Microbiology Laboratory, Public Health Agency of Canada, Winnipeg, Manitoba, Canada, Department of Medical Microbiology and Infectious Diseases, University of Manitoba, Winnipeg, Manitoba, Canada
⨯
Rhiannon L. C. H. Huzarewich,

Affiliation Molecular PathoBiology, National Microbiology Laboratory, Public Health Agency of Canada, Winnipeg, Manitoba, Canada
⨯
Kathy Manguiat,

Affiliation Molecular PathoBiology, National Microbiology Laboratory, Public Health Agency of Canada, Winnipeg, Manitoba, Canada
⨯
Sarah Medina,

Affiliation Molecular PathoBiology, National Microbiology Laboratory, Public Health Agency of Canada, Winnipeg, Manitoba, Canada
⨯
Catherine Robertson,

Affiliation Molecular PathoBiology, National Microbiology Laboratory, Public Health Agency of Canada, Winnipeg, Manitoba, Canada
⨯
Stephanie A. Booth

* E-mail: Stephanie.Booth@phac-aspc.gc.ca

Affiliations Molecular PathoBiology, National Microbiology Laboratory, Public Health Agency of Canada, Winnipeg, Manitoba, Canada, Department of Medical Microbiology and Infectious Diseases, University of Manitoba, Winnipeg, Manitoba, Canada
⨯

MicroRNA 146a (miR-146a) Is Over-Expressed during Prion Disease and Modulates the Innate Immune Response and the Microglial Activation State

Reuben Saba,
Shantel Gushue,
Rhiannon L. C. H. Huzarewich,
Kathy Manguiat,
Sarah Medina,
Catherine Robertson,
Stephanie A. Booth

Published: February 17, 2012
https://doi.org/10.1371/journal.pone.0030832

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MicroRNAs
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Microglial cells
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Cytokines
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Toll-like receptors
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Transfection
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Transcription factors
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Animal prion diseases
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Immune receptor signaling
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