Coronavirus Papain-like Proteases Negatively Regulate Antiviral Innate Immune Response through Disruption of STING-Mediated Signaling

Li Sun; Yaling Xing; Xiaojuan Chen; Yang Zheng; Yudong Yang; Daniel B. Nichols; Mark A. Clementz; Bridget S. Banach; Kui Li; Susan C. Baker; Zhongbin Chen

doi:10.1371/journal.pone.0030802

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Open Access

Peer-reviewed

Research Article

Coronavirus Papain-like Proteases Negatively Regulate Antiviral Innate Immune Response through Disruption of STING-Mediated Signaling

Li Sun ,

Contributed equally to this work with: Li Sun, Yaling Xing

Affiliation Division of Infection and Immunity, Department of Electromagnetic and Laser Biology, Beijing Institute of Radiation Medicine, Beijing, China
⨯
Yaling Xing ,

Contributed equally to this work with: Li Sun, Yaling Xing

Affiliation Division of Infection and Immunity, Department of Electromagnetic and Laser Biology, Beijing Institute of Radiation Medicine, Beijing, China
⨯
Xiaojuan Chen,

Affiliation Division of Infection and Immunity, Department of Electromagnetic and Laser Biology, Beijing Institute of Radiation Medicine, Beijing, China
⨯
Yang Zheng,

Affiliation Division of Infection and Immunity, Department of Electromagnetic and Laser Biology, Beijing Institute of Radiation Medicine, Beijing, China
⨯
Yudong Yang,

Affiliation Division of Infection and Immunity, Department of Electromagnetic and Laser Biology, Beijing Institute of Radiation Medicine, Beijing, China
⨯
Daniel B. Nichols,

Affiliation Department of Microbiology and Immunology, Loyola University of Chicago Stritch School of Medicine, Maywood, Illinois, United States of America
⨯
Mark A. Clementz,

Affiliation Department of Microbiology and Immunology, Loyola University of Chicago Stritch School of Medicine, Maywood, Illinois, United States of America
⨯
Bridget S. Banach,

Affiliation Department of Microbiology and Immunology, Loyola University of Chicago Stritch School of Medicine, Maywood, Illinois, United States of America
⨯
Kui Li,

Affiliation Department of Microbiology, Immunology and Biochemistry, University of Tennessee Health Science Center, Memphis, Tennessee, United States of America
⨯
Susan C. Baker ,

* E-mail: sbaker1@lumc.edu (SCB); chenzb@bmi.ac.cn (ZC)

Affiliation Department of Microbiology and Immunology, Loyola University of Chicago Stritch School of Medicine, Maywood, Illinois, United States of America
⨯
Zhongbin Chen

* E-mail: sbaker1@lumc.edu (SCB); chenzb@bmi.ac.cn (ZC)

Affiliation Division of Infection and Immunity, Department of Electromagnetic and Laser Biology, Beijing Institute of Radiation Medicine, Beijing, China
⨯

Coronavirus Papain-like Proteases Negatively Regulate Antiviral Innate Immune Response through Disruption of STING-Mediated Signaling

Li Sun,
Yaling Xing,
Xiaojuan Chen,
Yang Zheng,
Yudong Yang,
Daniel B. Nichols,
Mark A. Clementz,
Bridget S. Banach,
Kui Li,
Susan C. Baker

Published: February 1, 2012
https://doi.org/10.1371/journal.pone.0030802

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