Hypoxia-Induced Down-Regulation of microRNA-34a Promotes EMT by Targeting the Notch Signaling Pathway in Tubular Epithelial Cells

Rui Du; Wenjuan Sun; Lin Xia; Ali Zhao; Yan Yu; Lijuan Zhao; Hanmin Wang; Chen Huang; Shiren Sun

doi:10.1371/journal.pone.0030771

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Open Access

Peer-reviewed

Research Article

Hypoxia-Induced Down-Regulation of microRNA-34a Promotes EMT by Targeting the Notch Signaling Pathway in Tubular Epithelial Cells

Rui Du ,

Contributed equally to this work with: Rui Du, Wenjuan Sun, Lin Xia, Ali Zhao

Affiliation Department of Nephrology, Xijing Hospital, Fourth Military Medical University, Xi'an, People's Republic China
⨯
Wenjuan Sun ,

Contributed equally to this work with: Rui Du, Wenjuan Sun, Lin Xia, Ali Zhao

Affiliation Department of Nephrology, Xijing Hospital, Fourth Military Medical University, Xi'an, People's Republic China
⨯
Lin Xia ,

Contributed equally to this work with: Rui Du, Wenjuan Sun, Lin Xia, Ali Zhao

Affiliation State Key Laboratory of Cancer Biology & Xijing Digestive Hospital, Fourth Military Medical University, Xi'an, People's Republic China
⨯
Ali Zhao ,

Contributed equally to this work with: Rui Du, Wenjuan Sun, Lin Xia, Ali Zhao

Affiliation Department of Nephrology, Xijing Hospital, Fourth Military Medical University, Xi'an, People's Republic China
⨯
Yan Yu,

Affiliation Department of Nephrology, Xijing Hospital, Fourth Military Medical University, Xi'an, People's Republic China
⨯
Lijuan Zhao,

Affiliation Department of Nephrology, Xijing Hospital, Fourth Military Medical University, Xi'an, People's Republic China
⨯
Hanmin Wang,

Affiliation Department of Nephrology, Xijing Hospital, Fourth Military Medical University, Xi'an, People's Republic China
⨯
Chen Huang ,

* E-mail: Chenhuang@fmmu.edu.cn (CH); Sunshiren@fmmu.edu.cn (SS)

Affiliation Department of Nephrology, Xijing Hospital, Fourth Military Medical University, Xi'an, People's Republic China
⨯
Shiren Sun

* E-mail: Chenhuang@fmmu.edu.cn (CH); Sunshiren@fmmu.edu.cn (SS)

Affiliation Department of Nephrology, Xijing Hospital, Fourth Military Medical University, Xi'an, People's Republic China
⨯

Hypoxia-Induced Down-Regulation of microRNA-34a Promotes EMT by Targeting the Notch Signaling Pathway in Tubular Epithelial Cells

Rui Du,
Wenjuan Sun,
Lin Xia,
Ali Zhao,
Yan Yu,
Lijuan Zhao,
Hanmin Wang,
Chen Huang,
Shiren Sun

Published: February 17, 2012
https://doi.org/10.1371/journal.pone.0030771

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30 Aug 2012
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Responses to Reader's Comments posted on behalf of the Authors Posted by PLOS_ONE_Group on 30 Aug 2012 at 13:41 GMT
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Experimental design queries Posted by kwitwer1 on 09 Apr 2012 at 02:53 GMT
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miR-210 and miR-200 family Posted by pfasanaro on 02 Mar 2012 at 14:36 GMT

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MicroRNAs
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Hypoxia
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Transfection
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Epithelial cells
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Notch signaling
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Small interfering RNA
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Medical hypoxia
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