PDGF Upregulates Mcl-1 Through Activation of β-Catenin and HIF-1α-Dependent Signaling in Human Prostate Cancer Cells

Shareen Iqbal; Shumin Zhang; Adel Driss; Zhi-Ren Liu; Hyeong-Reh Choi Kim; Yanru Wang; Chad Ritenour; Haiyen E. Zhau; Omer Kucuk; Leland W. K. Chung; Daqing Wu

doi:10.1371/journal.pone.0030764

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Open Access

Peer-reviewed

Research Article

PDGF Upregulates Mcl-1 Through Activation of β-Catenin and HIF-1α-Dependent Signaling in Human Prostate Cancer Cells

Shareen Iqbal,

Affiliation Department of Urology and Winship Cancer Institute, Emory University School of Medicine, Atlanta, Georgia, United States of America
⨯
Shumin Zhang,

Affiliation Department of Urology and Winship Cancer Institute, Emory University School of Medicine, Atlanta, Georgia, United States of America
⨯
Adel Driss,

Affiliation Department of Microbiology, Biochemistry and Immunology, Morehouse School of Medicine, Atlanta, Georgia, United States of America
⨯
Zhi-Ren Liu,

Affiliation Department of Biology, Georgia State University, Atlanta, Georgia, United States of America
⨯
Hyeong-Reh Choi Kim,

Affiliation Department of Pathology, Barbara Ann Karmanos Cancer Institute, Wayne State University, School of Medicine, Detroit, Michigan, United States of America
⨯
Yanru Wang,

Affiliation Department of Urology and Winship Cancer Institute, Emory University School of Medicine, Atlanta, Georgia, United States of America
⨯
Chad Ritenour,

Affiliation Department of Urology and Winship Cancer Institute, Emory University School of Medicine, Atlanta, Georgia, United States of America
⨯
Haiyen E. Zhau,

Affiliation Uro-Oncology Research Program, Department of Medicine, Cedars-Sinai Medical Center, Los Angeles, California, United States of America
⨯
Omer Kucuk,

Affiliation Department of Hematology and Medical Oncology and Winship Cancer Institute, Emory University School of Medicine, Atlanta, Georgia, United States of America
⨯
Leland W. K. Chung ,

* E-mail: dwu2@emory.edu (DW); Leland.Chung@cshs.org (LWKC)

Affiliation Uro-Oncology Research Program, Department of Medicine, Cedars-Sinai Medical Center, Los Angeles, California, United States of America
⨯
Daqing Wu

* E-mail: dwu2@emory.edu (DW); Leland.Chung@cshs.org (LWKC)

Affiliation Department of Urology and Winship Cancer Institute, Emory University School of Medicine, Atlanta, Georgia, United States of America
⨯

PDGF Upregulates Mcl-1 Through Activation of β-Catenin and HIF-1α-Dependent Signaling in Human Prostate Cancer Cells

Shareen Iqbal,
Shumin Zhang,
Adel Driss,
Zhi-Ren Liu,
Hyeong-Reh Choi Kim,
Yanru Wang,
Chad Ritenour,
Haiyen E. Zhau,
Omer Kucuk,
Leland W. K. Chung

Published: January 20, 2012
https://doi.org/10.1371/journal.pone.0030764

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23 Jan 2012
16:10 GMT
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Outstanding! Posted by adriss on 23 Jan 2012 at 16:10 GMT

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