Nox4 Mediates Renal Cell Carcinoma Cell Invasion through Hypoxia-Induced Interleukin 6- and 8- Production

John P. Fitzgerald; Bijaya Nayak; Karthigayan Shanmugasundaram; William Friedrichs; Sunil Sudarshan; Assaad A. Eid; Thomas DeNapoli; Dipen J. Parekh; Yves Gorin; Karen Block

doi:10.1371/journal.pone.0030712

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Peer-reviewed

Research Article

Nox4 Mediates Renal Cell Carcinoma Cell Invasion through Hypoxia-Induced Interleukin 6- and 8- Production

John P. Fitzgerald,

Affiliation Department of Urology, University of Texas Health Science Center, San Antonio, Texas, United States of America
⨯
Bijaya Nayak,

Affiliation Division of Nephrology, Department of Medicine, University of Texas Health Science Center, San Antonio, Texas, United States of America
⨯
Karthigayan Shanmugasundaram,

Affiliation Department of Urology, University of Texas Health Science Center, San Antonio, Texas, United States of America
⨯
William Friedrichs,

Affiliation Division of Nephrology, Department of Medicine, University of Texas Health Science Center, San Antonio, Texas, United States of America
⨯
Sunil Sudarshan,

Affiliation Department of Urology, University of Texas Health Science Center, San Antonio, Texas, United States of America
⨯
Assaad A. Eid,

Affiliation Division of Nephrology, Department of Medicine, University of Texas Health Science Center, San Antonio, Texas, United States of America
⨯
Thomas DeNapoli,

Affiliation Department of Pathology, University of Texas Health Science Center, San Antonio, Texas, United States of America
⨯
Dipen J. Parekh,

Affiliation Department of Urology, University of Texas Health Science Center, San Antonio, Texas, United States of America
⨯
Yves Gorin,

Affiliation Division of Nephrology, Department of Medicine, University of Texas Health Science Center, San Antonio, Texas, United States of America
⨯
Karen Block

* E-mail: block@uthscsa.edu

Affiliations Audie L. Murphy Memorial Hospital Division, South Texas Veterans Health Care System, University of Texas Health Science Center, San Antonio, Texas, United States of America, Division of Nephrology, Department of Medicine, University of Texas Health Science Center, San Antonio, Texas, United States of America
⨯

Nox4 Mediates Renal Cell Carcinoma Cell Invasion through Hypoxia-Induced Interleukin 6- and 8- Production

John P. Fitzgerald,
Bijaya Nayak,
Karthigayan Shanmugasundaram,
William Friedrichs,
Sunil Sudarshan,
Assaad A. Eid,
Thomas DeNapoli,
Dipen J. Parekh,
Yves Gorin,
Karen Block

Published: January 27, 2012
https://doi.org/10.1371/journal.pone.0030712

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Hypoxia
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Renal cancer
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Transfection
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