TIM-3 Expression Characterizes Regulatory T Cells in Tumor Tissues and Is Associated with Lung Cancer Progression

Xin Gao; Yibei Zhu; Gang Li; Haitao Huang; Guangbo Zhang; Fengming Wang; Jing Sun; Qianting Yang; Xueguang Zhang; Binfeng Lu

doi:10.1371/journal.pone.0030676

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Open Access

Peer-reviewed

Research Article

TIM-3 Expression Characterizes Regulatory T Cells in Tumor Tissues and Is Associated with Lung Cancer Progression

Xin Gao ,

Contributed equally to this work with: Xin Gao, Yibei Zhu

Affiliation Department of Immunology, Institute of Medical Biotechnology, Soochow University, Suzhou, People's Republic of China
⨯
Yibei Zhu ,

Contributed equally to this work with: Xin Gao, Yibei Zhu

Affiliations Department of Immunology, Institute of Medical Biotechnology, Soochow University, Suzhou, People's Republic of China, Department of Immunology, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America
⨯
Gang Li,

Affiliation Department of Immunology, Institute of Medical Biotechnology, Soochow University, Suzhou, People's Republic of China
⨯
Haitao Huang,

Affiliation Jiangsu Institute of Clinical Immunology, The First Affiliated Hospital of Soochow University, Suzhou, People's Republic of China
⨯
Guangbo Zhang,

Affiliation Jiangsu Institute of Clinical Immunology, The First Affiliated Hospital of Soochow University, Suzhou, People's Republic of China
⨯
Fengming Wang,

Affiliation Department of Immunology, Institute of Medical Biotechnology, Soochow University, Suzhou, People's Republic of China
⨯
Jing Sun,

Affiliation Department of Immunology, Institute of Medical Biotechnology, Soochow University, Suzhou, People's Republic of China
⨯
Qianting Yang,

Affiliation Shenzhen Clinical Center for Infectious Diseases, Shenzhen Third People's Hospital, Shenzhen, People's Republic of China
⨯
Xueguang Zhang ,

* E-mail: binfeng@pitt.edu (BL); xueguangzh@yahoo.com.cn (XZ)

Affiliations Department of Immunology, Institute of Medical Biotechnology, Soochow University, Suzhou, People's Republic of China, Jiangsu Province Key Laboratory of Stem Cell Research, Soochow University, Suzhou, People's Republic of China
⨯
Binfeng Lu

* E-mail: binfeng@pitt.edu (BL); xueguangzh@yahoo.com.cn (XZ)

Affiliations Department of Immunology, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America, University of Pittsburgh Cancer Institute, Pittsburgh, Pennsylvania, United States of America
⨯

TIM-3 Expression Characterizes Regulatory T Cells in Tumor Tissues and Is Associated with Lung Cancer Progression

Xin Gao,
Yibei Zhu,
Gang Li,
Haitao Huang,
Guangbo Zhang,
Fengming Wang,
Jing Sun,
Qianting Yang,
Xueguang Zhang,
Binfeng Lu

Published: February 17, 2012
https://doi.org/10.1371/journal.pone.0030676

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Non-small cell lung cancer
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