Biochemical Discrimination between Selenium and Sulfur 1: A Single Residue Provides Selenium Specificity to Human Selenocysteine Lyase

Ruairi Collins; Ann-Louise Johansson; Tobias Karlberg; Natalia Markova; Susanne van den Berg; Kenneth Olesen; Martin Hammarström; Alex Flores; Herwig Schüler; Lovisa Holmberg Schiavone; Peter Brzezinski; Elias S. J. Arnér; Martin Högbom

doi:10.1371/journal.pone.0030581

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Peer-reviewed

Research Article

Biochemical Discrimination between Selenium and Sulfur 1: A Single Residue Provides Selenium Specificity to Human Selenocysteine Lyase

Ruairi Collins,

Affiliation Structural Genomics Consortium, Department of Medical Biochemistry and Biophysics, Karolinska Institute, Stockholm, Sweden
⨯
Ann-Louise Johansson,

Affiliation Stockholm Center for Biomembrane Research, Department of Biochemistry and Biophysics, Arrhenius Laboratories for Natural Sciences C4, Stockholm University, Stockholm, Sweden
⨯
Tobias Karlberg,

Affiliation Structural Genomics Consortium, Department of Medical Biochemistry and Biophysics, Karolinska Institute, Stockholm, Sweden
⨯
Natalia Markova,

Affiliation Structural Genomics Consortium, Department of Medical Biochemistry and Biophysics, Karolinska Institute, Stockholm, Sweden
⨯
Susanne van den Berg,

Affiliation Structural Genomics Consortium, Department of Medical Biochemistry and Biophysics, Karolinska Institute, Stockholm, Sweden
⨯
Kenneth Olesen,

Current address: Nanoxis AB, Gothenburg, Sweden

Affiliation Structural Genomics Consortium, Department of Medical Biochemistry and Biophysics, Karolinska Institute, Stockholm, Sweden
⨯
Martin Hammarström,

Affiliation Structural Genomics Consortium, Department of Medical Biochemistry and Biophysics, Karolinska Institute, Stockholm, Sweden
⨯
Alex Flores,

Affiliation Structural Genomics Consortium, Department of Medical Biochemistry and Biophysics, Karolinska Institute, Stockholm, Sweden
⨯
Herwig Schüler,

Affiliation Structural Genomics Consortium, Department of Medical Biochemistry and Biophysics, Karolinska Institute, Stockholm, Sweden
⨯
Lovisa Holmberg Schiavone,

Current address: Cells, Proteins and Structural Sciences AstraZeneca, Mölndal, Sweden

Affiliation Structural Genomics Consortium, Department of Medical Biochemistry and Biophysics, Karolinska Institute, Stockholm, Sweden
⨯
Peter Brzezinski,

Affiliation Stockholm Center for Biomembrane Research, Department of Biochemistry and Biophysics, Arrhenius Laboratories for Natural Sciences C4, Stockholm University, Stockholm, Sweden
⨯
Elias S. J. Arnér,

Affiliation Division of Biochemistry, Department of Medical Biochemistry and Biophysics, Karolinska Institutet, Stockholm, Sweden
⨯
Martin Högbom

* E-mail: hogbom@dbb.su.se

Affiliations Structural Genomics Consortium, Department of Medical Biochemistry and Biophysics, Karolinska Institute, Stockholm, Sweden, Stockholm Center for Biomembrane Research, Department of Biochemistry and Biophysics, Arrhenius Laboratories for Natural Sciences C4, Stockholm University, Stockholm, Sweden
⨯

Biochemical Discrimination between Selenium and Sulfur 1: A Single Residue Provides Selenium Specificity to Human Selenocysteine Lyase

Ruairi Collins,
Ann-Louise Johansson,
Tobias Karlberg,
Natalia Markova,
Susanne van den Berg,
Kenneth Olesen,
Martin Hammarström,
Alex Flores,
Herwig Schüler,
Lovisa Holmberg Schiavone

Published: January 25, 2012
https://doi.org/10.1371/journal.pone.0030581

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Crystal structure
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